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Diss Factsheets
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EC number: 601-478-9 | CAS number: 117428-22-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
- GLP compliance:
- yes
Test material
- Reference substance name:
- methyl (E)-3-methoxy-2-{2-[6-(trifluoromethyl)pyridin-2-yloxymethyl]phenyl}acrylate
- EC Number:
- 601-478-9
- Cas Number:
- 117428-22-5
- Molecular formula:
- C18H16F3NO4
- IUPAC Name:
- methyl (E)-3-methoxy-2-{2-[6-(trifluoromethyl)pyridin-2-yloxymethyl]phenyl}acrylate
- Test material form:
- solid
- Details on test material:
- - Purity: 93.3-99.8% (see individual test record for specific details)
Constituent 1
- Specific details on test material used for the study:
- 93.3% purity
Administration / exposure
- Type of coverage:
- other: In vitro
- Remarks:
- Human epidermis tissue
- Vehicle:
- acetone
- Duration of exposure:
- 55 hours
- Doses:
- 0.1 g/cm2 (undiluted solid) and 40 μg/cm2 (acetone solution)
- Details on in vitro test system (if applicable):
- The absorption of the test substance has been measured in vitro through human epidermis. The material was applied undiluted and as a 1600 μg/mL solution in acetone. The undiluted material was applied as a dry powder to epidermal membranes as an infinite at a rate of 0.1 g/cm2 and occluded for the duration of the exposure period (55 hours), while the solution in acetone was applied at 25 μL/cm2 (40 μg/cm2) and left unoccluded throughout the entire exposure period allowing the acetone vehicle to evaporate and the test substance to remain as a dried-on deposit.
Results and discussion
- Absorption in different matrices:
- No absorption of the solid test substance was detected from the undiluted technical grade material (<0.017 μg/cm2/h) until 8 hours after application. After this time absorption maintained an unchanging rate (0.020 μg/cm2/h) until the end of the exposure period (55 hours).
From the 40 μg/cm2 dried-on deposit from the 1600 μg/ml solution in acetone, test substance absorption after the first hour of exposure maintained a constant rate of 0.076 μg/cm2/h.
Applicant's summary and conclusion
- Conclusions:
- When applied as a dry powder and in excess, absorption of the test substance through human epidermis is very slow from unformulated technical grade material, when compared with the absorption rates of other penetrants measured using this in vitro technique. Following evaporation of the acetone vehicle, absorption from the dried-on deposit also indicates a very slow rate of human skin penetration for the test substance.
- Executive summary:
The absorption of the test substance has been measured in vitro through human epidermis. The material was applied undiluted and as a 1600 μg/mL solution in acetone. The undiluted material was applied as a dry powder to epidermal membranes as an infinite at a rate of 0.1 g/cm2 and occluded for the duration of the exposure period (55 hours), while the solution in acetone was applied at 25 μL/cm2 (40 μg/cm2) and left unoccluded throughout the entire exposure period allowing the acetone vehicle to evaporate and the test substance to remain as a dried-on deposit.
No absorption of the solid test substance was detected from the undiluted technical grade material (<0.017 μg/cm2/h) until 8 hours after application. After this time absorption maintained an unchanging rate (0.020 μg/cm2/h) until the end of the exposure period (55 hours). From the 40 μg/cm2 dried-on deposit from the 1600 μg/mL solution in acetone, test substance absorption after the first hour of exposure maintained a constant rate of 0.076 μg/cm2/h.
When applied as a dry powder and in excess, absorption of the test substance through human epidermis is very slow from unformulated technical grade material, when compared with the absorption rates of other penetrants measured using this in vitro technique. Following evaporation of the acetone vehicle, absorption from the dried-on deposit also indicates a very slow rate of human skin penetration for the test substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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