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Diss Factsheets
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EC number: 296-719-4 | CAS number: 93028-28-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Between 30 October 1986 and 13 November 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 40 CFR, Section 163.81-2, Federal Register, August 22, 1978
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 61789-86-4
- IUPAC Name:
- 61789-86-4
- Reference substance name:
- 293-093-9
- IUPAC Name:
- 293-093-9
- Details on test material:
- Test Article : OS# 68022B
Description : Dark brown liquid
Test Article Received : 10/13/86
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The New Zealand White rabbit, weighing 2.0 to 3.0 kg, was used for this study. The animals were obtained from Buckshire, Corp., Perkasie PA 18944 (U.S.D.A. License (#23-BL).
The animals were individually housed and maintained in accordance with standards set forth in the Guide for the Care and Use of Laboratory Animals (DHEW Publication No. 80-23). The rabbits were acclimated to the laboratory for at least 5 days prior to dosing.
The animals were individually identified by an ear tag and each cage was identified with a cage card.
Husbandry Conditions:
Relative Humidity,%: 55 ± 25
Temperature: 60°F - 75°F
Light: 12 hour light/dark cycle
Diet: Wayne 15% Rabbit Ration and tap water were provided ad libitum. Based on our current knowledge, no contaminants are known to be in this diet or water which might be expected to interfere with the objectives of the study.
Caging: Stainless steel with elevated wire mesh flooring, 1 rabbit/cage.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The Test Article was dosed as supplied, at a dose level of 4.0 g/kg.
- Duration of exposure:
- 24 hours
- Doses:
- 4.0 gm /kg body weight
- No. of animals per sex per dose:
- 5 male
5 female - Control animals:
- not required
- Details on study design:
- The test article was dosed as supplied at a dose level of 4.0 g/kg.
A group of 10 rabbits (5 male & 5 female) with healthy intact skin was used. Approximately 24 hours before testing the fur was clipped from the backs of the test animals.
All rabbits were weighed and the correct amount of Test Article was applied to approximately 10% of the body surface on each animal. The treated area was covered with a large porous gauze patch and wrapped with an impervious material to ensure that the animal did not ingest the Test Article. The dressings were removed after 24 hours and any excess material removed, where practical, using water or an appropriate solvent.
The animals were observed for a 14 day period for signs of toxicity (systemic and topical) and for mortalities. Animals were observed frequently during the first day of dosing, and twice per day (morning and afternoon) on weekdays. On weekends and holidays, animals were observed once per day. Individual weights were recorded on the day of dosing, weekly thereafter, and prior to sacrifice. The animals were euthanized using T-61 at the conclusion of the observation period. Gross necropsies were performed on all animals. - Statistics:
- No statistical analysis was performed.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 4 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 95% confidence limits not reported.
- Mortality:
- See Table 1 (attachment 1) for individual mortality data
One female animal died during the study - Clinical signs:
- See Table 2 (attachment 2) for Observations data
- Body weight:
- See Table 1-(attachment 1) for average bodyweight data
- Gross pathology:
- See Table 2 (attachment 2) for Pathology data
- Other findings:
- None.
Applicant's summary and conclusion
- Interpretation of results:
- other: acute dermal LD50 greater than 4.0 g/kg.
- Remarks:
- Criteria used for interpretation of results: expert judgment
- Conclusions:
- The Test Article when dosed as supplied and studied in 5 male and 5 female albino rabbits, appears to have an acute dermal LD50 greater than 4.0 g/kg.
- Executive summary:
Introduction: To determine the acute dermal toxicity of the Test Article in rabbits. Method: The Test Article was dosed as supplied, at a dose level of 4.0 g/kg. A group of 10 rabbits (5 male & 5 female) with healthy intact skin was used. The animals were observed for a 14 day period for signs of toxicity (systemic and topical) and for mortalities. Conclusion: Test Article when dosed as supplied appears to have an acute dermal LD50 greater than 4.0 g/kg.
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