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Diss Factsheets
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EC number: 298-995-1 | CAS number: 93841-25-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- A read-across with the analogue substance 2-(2,5-diaminophenyl)ethanol dihydrochloride is proposed. The substance detailed in section 1 and the analogue material are both salts of 2-(2,5-diaminophenyl)ethanol with similar physical and chemical properties.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Determination of the local compatibility of the test substance by repeated open-epicutaneous application to the albino guinea pig following the method according to Draize. 3% dilution of 1-beta-hydroxyethyl-2,5-diaminobenzene dihydrochloride in 0.5% aqueous tylose was applied onto the clipped flank region of 15 albino Guinea pigs for 5 consecutive days.. The skin was not covered but animals were restrained from movement during the first 5 hours. Possible skin reactions were evaluated for erythema and oedema 5 hours after each application.
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-Beta-hydroxyethyl-2,5-diaminobenzene dihydrochloride
- Molecular formula:
- C8H12N2O.2HCl
- IUPAC Name:
- 1-Beta-hydroxyethyl-2,5-diaminobenzene dihydrochloride
1
Test animals
- Species:
- guinea pig
- Strain:
- other: White Pirbright (SPF)
Test system
- Type of coverage:
- open
- Preparation of test site:
- clipped
- Vehicle:
- other: 0.5% aqueous tylose
- Controls:
- no
- Amount / concentration applied:
- 3% dissolved in 0.5% aqueous tylose
- Duration of treatment / exposure:
- Five days
- Observation period:
- Five hours after each application
- Number of animals:
- Fifteen females
- Details on study design:
- The test substance was open-epicutaneously applied to the clipped (Elektra II GH204 hair clipper fitted with 1/20 clipper head, Aeskulap Inc.) flank skin (3 x 4cm) of the alino guinea pigs following the method according to Draize.
Application : The test substance was applied daily using a brush and was not removed by washing. The assessment of the skin reactions was performed daily five hours after the application. The overall exposure duration was 5 days.
Analysis : The following criteria were considered in the evaluation of the skin reactions after each treatment and during the observation period ; 1) erythema and eschar formation, 2) oedema formation, 3) behaviour and general conditions of the animals.
Determination of the results : The skin reactions were determined by two persons independently of each other and the mead calculated. The assessment of the skin reactions was conducted according to the scoring system of Draize.
Animal husbandry : The guinea pigs were fixed in individual boxes during the treatment phase so that contact with the treated flank either by themselves or by other animals was impossible. During the following observation period, the animals were kept in wire cages. All animals received a standard laboratory diet and drinking water ad libitum.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No erythematous skin reactions were noticed during the entire observation period. Other symptoms of inflammation such as oedema were not observed. Necrosis or wheals did not occur. The 3% solution of the test substance is clasified as not irritating.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- No indication of a skin irritating potential of 1-beta-hydroxyethyl-2,5-diaminobenzene dihydrochloride tested at a 3% aqueous solution in a repeated application assay in Guinea pigs was noted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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