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Diss Factsheets
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EC number: 257-048-2 | CAS number: 51200-87-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Only 10 days observation period applied.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not applicable
- Remarks:
- only male rats were tested, observation period only 10 days
- Principles of method if other than guideline:
- No information on guideline followed.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4,4-dimethyloxazolidine
- EC Number:
- 257-048-2
- EC Name:
- 4,4-dimethyloxazolidine
- Cas Number:
- 51200-87-4
- Molecular formula:
- C5H11NO
- IUPAC Name:
- 4,4-dimethyl-1,3-oxazolidine
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Test material name: Oxazolidine-A
- Lot No. of test material: 575916
- Purity: 87.4%
Test animals
- Species:
- rat
- Strain:
- other: Holtzman
- Remarks:
- albino rats
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not specified
- Age at study initiation: not specified; young adults
- Weight at study initiation: 150-180 grams
- Fasting period before study: overnight
- Food and water ad libitum
- Acclimation period: not specified
ENVIRONMENTAL CONDITIONS
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: Dosage volume was 0.04 mL/g body weight.
- Doses:
- 400, 630, 1000,1600, and 2500 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 10 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes, gross necropsies were performed after the observation period
Results and discussion
- Preliminary study:
- Preliminary examination indicated a LD50 of between 800 and 2000 mg/kg.
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 956 mg/kg bw
- Based on:
- test mat.
- Remarks:
- diluted with distilled water
- Remarks on result:
- other: determined by Spearman Karber method
- Mortality:
- Numbers of dead rats per dose:
400 mg/kg: 0; 630 mg/kg: 0; 1000 mg/kg: 3; 1600 mg/kg: 5; 2500 mg/kg: 5
The times of death of animals receiving the 1600 and 2500 mg/kg doses were within 2 minutes at the higher dose and approx. 5 minutes for the lower dose. Animals which had received the 1000 mg/kg dose died as follows: one dead within 24 hours after administration; one dead within 48 hours; one dead within 96 hours. - Gross pathology:
- Necropsy findings: animals which died acutely where in rigor; hearts arrested in systole. Livers engorged with blood. No remarcable findings at necropsy of animal which died during or after the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The oral LD50 in rats was determined to be 956 mg/kg for the test item (CAS: 51200-87-4).
- Executive summary:
The oral LD50 in rats was determined by gavage to male rats to be 956 mg/kg for the test item (CAS: 51200-87-4).
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