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EC number: 619-817-4 | CAS number: 52671-72-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Test performed prior to the implementation of the current acknowledged testing and GLP guidelines . The test conduct however was in principle very similar to the OECD TG 401 as adopted in 1981. Important aspects (e.g. 14 day-postobservation time) were considered.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: According to company guideline similar to OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- pre-guideline study
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,4-dioxo-3-oxatricyclo[7.3.1.0⁵,¹³]trideca-1(13),5,7,9,11-pentaene-8,10-dicarboxylic acid
- EC Number:
- 619-817-4
- Cas Number:
- 52671-72-4
- Molecular formula:
- C14H6O7
- IUPAC Name:
- 2,4-dioxo-3-oxatricyclo[7.3.1.0⁵,¹³]trideca-1(13),5,7,9,11-pentaene-8,10-dicarboxylic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain specifics: Wistar, SPF-Albino
- Source: Hoechst, breeding colony
- Weight at study initiation: 202 g - 228 g, mean 219 g) on day 1 (treatment)
- Fasting period before study: approximately 16 hours before treatment
- Housing: plastic cages with softwood bedding
- Diet: Altromin 1324 ad libitum
- Water: tap water ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25 % suspension - Doses:
- 2 500 mg/kg body weight
3 150 mg/kg body weight
4 000 mg/kg body weight
5 000 mg/kg body weight - No. of animals per sex per dose:
- 10 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, macroscopic examination - Statistics:
- None
Results and discussion
- Preliminary study:
- No differences between males and females were determined in preliminary tests. 250 mg/kg bw were administered to groups of 4 males and 4 females respectively, 1000 and 5000 mg/kg bw were administered to groups of 3 males and 3 females respectively. In the highest dose group one female died.
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3 508 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortalities were observed at every dose level in the main study (see table below). Animals died within 2 to 6 days after administration of the test substance.
- Clinical signs:
- other: Crouched position, prone position, slightly increased respiration rate.
- Gross pathology:
- No abnormal macroscopic findings at scheduled necropsy in surviving animals and in animals found dead.
- Other findings:
- No other findigs
Any other information on results incl. tables
dose [mg/kg body weight] |
number of animals |
mortalities |
2 500 |
10 |
4 |
3 150 |
10 |
6 |
4 000 |
10 |
5 |
5 000 |
10 |
9 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Single application of 2500, 3150, 4000 and 5000 mg per kg bw test item respectively did cause graduated lethality to female rats during the 14 days observation period. According to the method of Kärber the LD50 was calculated to be 3508 mg/kg bw.
- Executive summary:
Female rats were subjected to test acute oral toxicity. The test item was administered at doses of 2500, 3150, 4000 and 5000 mg/kg bw to 10 female rats respectively. During the 14 days observation period animals died at any dose level. According to the method of Kärber the LD50 was calculated to be 3508 mg/kg bw.
Therefore, the test item has not to be classified for acute oral toxicity according to Regulation (EC) No 1272/2008.
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