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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Additional information
Acute and chronic data are available with different flags and reliability for three aquatic trophic levels: Algae, Invertebrates and Fish and are summarised in the table below:
Level of exposure / trophic levels | Test substance | Organisms | L(E)C50 | L(E)C10 / NOEC | Flag/Reliability | Comments | Reference in IUCLID |
Acute / Fish | Registered substance | Oncorhynchus mykiss | 96h: 0.93 mg/L | / | K/1 | based on mean measured concentrations | 18)OECD203_Acute tox to fish_107628-04-6_Harlan_C02823 |
Acute / Fish | Registered substance | Leuciscus idus melanotus | 96h: 3 mg/L | / | S/2 | Non-GLP | 1)No OECD_Acute tox Fish_107628-04-6_IF_68098 |
Acute / Aquatic invertebrates | Registered substance | Daphnia magna | 48h: 0.32 mg/L | / | K/1 | based on mean measured concentrations | 17)OECD202_Acute tox to Daphnia_107628-04-6_Harlan_C02812 |
Acute / Aquatic invertebrates | Registered substance | Daphnia magna | 48h: 1 mg/L | / | S/2 | Non-GLP | 2)No OECD_Acute tox Daphnia_107628-04-6_IF_68098 |
Acute and chronic / Aquatic algae | Registered substance | Desmodesmus subspicatus | 72h: >2.0 mg/L | 72h: 2.0 mg/L | K/2 | Based on the inhibition of the specific growth | 3)OECD201_toxicity towards algae_107628-04-6_IF_97 40095-00 |
Long-term / Fish | Registered substance | Oncorhynchus mykiss | / | 28d: 0.15 mg/L | K/1 | based on mean measured concentrations / Based on mortality, visible abnormalities, fish wet weight, and pseudo specific growth rate for fish wet weight | 19)OECD215_Fish 28d_107628-04-6_Harlan_C02856 |
Long-term / Aquatic invertebrates | Registered substance | Daphnia magna | / | 21d: 0.022 mg/L | K/1 | Based on mean measured concentrations calculated as time-weighted means of the test item concentrations | Long-term toxicity to aquatic invertebrates_C50808_2009 |
Toxicity to microorganisms | Registered substance | aerobic activated sludge | / | 3h-NOEC: 1000 mg/L | K/1 | Based on nominal concentrations | 16)OECD209_activated sludge_107628-04-6_Harlan_C50810 |
In short-term exposure, the key ecotoxicity values (L(E)C50) range between 0.32 and >2 mg/L for the three trophic levels (algae, aquatic invertebrates and fish). The results are based on studies performed according to the OECD guidelines and under GLP compliance. They are considered acceptable. The aquatic invertebrate Daphnia magna seems to be the most sensitive species with a 48h-EC50 of 0.32 mg/L based on mean measured concentrations.
Based on these results, the registered substance should be classified as acute 1 to aquatic organisms in accordance with the classification of the CLP.
In long-term exposure, the aquatic invertebrates Daphnia magna seems also to be the most sensitive species, with a 21d-NOEC of 0.022 mg/L, based on mean measured concentrations calculated as time-weighted means of the test item concentrations. In addition, data were available for long-term toxicity to fish and algae, with a 72h-NOECr for algae Desmodesmus subspicatus of 2.0 mg/L and a 28d-NOEC for the rainbow trout Oncorhynchus mykiss of 0.15 mg/L.
Finally, data was available to assess the inhibitory effect of the test item on the respiration rate of aerobic wastewater microorganisms of activated sludge in a 3-hour respiration inhibition test according to the OECD 209 Guideline and under GLP compliance. Up to and including the highest test concentration of 1000 mg/L, the test item had no significant inhibitory effect ( ≤10%) on the respiration rate of activated sludge after the incubation period of three hours. Based on the physical appearance of the test solution/dispersions, the saturation concentration (water solubility limit of the substance under the test conditions) was <100mg/L and resulted in less than 10% inhibition after three hours contact time. Thus, the 3 -hour NOEC of the test item to activated sludge microorganism was at the water solubility limit of the substance under the test conditions, or at 1000 mg/L. The 3 -hour EC20, EC50 and EC80 were clearly higher than the water solubility limit of the test item under the test conditions, or higher than 1000 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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