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Reaction mass of tetrasodium 3-[[4-[[4-[(6-amino-1-hydroxy-3-sulphonato-2-naphthyl)azo]-6-sulphonato-1-naphthyl]azo]-1-naphthyl]azo]naphthalene-1,5-disulphonate and tetrasodium 3-[[4-[[4-[(6-amino-1-hydroxy-3-sulphonato-2-naphthyl)azo]-7-sulphonato-1-naphthyl]azo]-1-naphthyl]azo]naphthalene-1,5-disulphonate
EC number: 911-640-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- tetrasodium 6-[(1E)-2-{4-[(1E)-2-{4-[(1E)-2-(6-amino-1-hydroxy-3-sulfonatonaphthalen-2-yl)diazen-1-yl]-7-sulfonatonaphthalen-1-yl}diazen-1-yl]naphthalen-1-yl}diazen-1-yl]naphthalene-1,4-disulfonate
- EC Number:
- 911-640-3
- Molecular formula:
- C40H27N7O13S4.4Na
- IUPAC Name:
- tetrasodium 6-[(1E)-2-{4-[(1E)-2-{4-[(1E)-2-(6-amino-1-hydroxy-3-sulfonatonaphthalen-2-yl)diazen-1-yl]-7-sulfonatonaphthalen-1-yl}diazen-1-yl]naphthalen-1-yl}diazen-1-yl]naphthalene-1,4-disulfonate
- Details on test material:
- SMILE notation for Vapour pressure
O=S(=O)(O[Na])c8cccc1c8cc(cc1S(=O)(=O)O[Na])/N=N/c7ccc(/N=N/c5ccc(/N=N/c2c(O)c3ccc(N)cc3cc2S(=O)(=O)O[Na])c4cc(ccc45)S(=O)(=O)O[Na])c6ccccc67
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- HealthySpregue-Dawley RAI.f. (SPF) (Ra25) derived rats were used. These were bred on the premises. Aged 6-7 weeks, and had an average body weight of 154 g. (male) and 127 g. (female).
Rats were caged singly and kept in a room maintained at a temperature of 21°C. Animals were subjected to 12 hours artificiale light and 12 hours darkness in each 24 hour period. A commercial autoclavable pelleted diet (Labsure CMR Rat and mouse nuts) was fed and lib. Water filtered at 0.45 micron was available at all times.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- A 25% w/v suspension of the compound in a 0.5% aqueous solution of carboxymethyl cellulose was administered as a single dose by gavage to rats which had been fasted for 18 hours, at a rate of 20ml/kg. (equivalent to 5g/kg of compound)
- Doses:
- 5g/kg
- No. of animals per sex per dose:
- 5 females and 5 males per dose
- Control animals:
- no
- Details on study design:
- After administration of the compound, the animals were observed for 14 days. Death and clinical symptoms were recorded. At the end of the observation period, surviving animals were killed by exsanguination under ether anaesthesia and an autopsy performed.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no death
- Clinical signs:
- other: no abnormalities
- Gross pathology:
- dark kidney surfaces in 3/5 male and 4/5 female animals
- Other findings:
- Black stained urine and faeces were seen from 3 hours up to 6 days post dose. No abnormalities were seen from day 7 until the study terminated on day 14. At terminal autopsy the only abnormalities noted were dark kidney surfaces in 3/5 male and 4/5 female animals.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classigied under Regulation 1272/2008
- Conclusions:
- The substance was tested for acute toxicity oral follwoing OECD 420. Under the experimental conditions the substance showed LD50 (LDo= > 5000 mg/kg and did not show any toxicity signs over the 14 days period of observation
- Executive summary:
The substance was tested following OECD 420. Ten rats, five males and five females, were kept and fed in the same conditions by a 25% w/v suspension of the compound in a 0.5% aqueous solution of carboxymethyl cellulose. The substance was administered as a single dose by gavage to rats which had been fasted for 18 hours, at a rate of 20ml/kg. (equivalent to 5mg/kg of compound). After administration of the compound, the animals were observed for 14 days. Deaths and clinical symptoms were recorded. No abnormalities were seen from day 7 until the study terminated on day 14. At terminal autopsy the only abnormalities noted were dark kidney surfaces in 3/5 male and 4/5 female animals. The substance can be considered as non toxic at doses ca. 5000 mg(kg bw
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