Registration Dossier
Registration Dossier
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EC number: 210-039-7 | CAS number: 603-41-8
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003-02-17 to 2003-02-25
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline study however; no data on substance purity was given.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- (1981)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 002/221/2002
- Type of method:
- column elution method
Test material
- Reference substance name:
- p,p'-(2-pyridylmethylene)bisphenol
- EC Number:
- 210-039-7
- EC Name:
- p,p'-(2-pyridylmethylene)bisphenol
- Cas Number:
- 603-41-8
- Molecular formula:
- C18H15NO2
- IUPAC Name:
- 4-[(4-hydroxyphenyl)(pyridin-2-yl)methyl]phenol
- Test material form:
- solid
1
Results and discussion
Water solubility
- Water solubility:
- >= 8.3 - <= 8.7 mg/L
- Temp.:
- 22 °C
- pH:
- 4.5
- Details on results:
- Preliminary test: the determined water solubility was lower than 10 mg/L.
Any other information on results incl. tables
The first test was performed with a water flow of 12.5 mL/h and the second with a water flow of 25 ml/L, both at a temperature of 22°C, assured by the thermostatic bath with recycling water.
mean value of 8.7 mg/L: SD 0.53 and C.V. 6.05%
mean value of 8.3 mg/L: SD 0.72 and C.V. 8.65%
Applicant's summary and conclusion
- Conclusions:
- The water solubility of the oxypicoline sample is 8.7 mg/L with a 12.5 mL/h water flow at 22°C and 8.3 mg/L with a 25 mL/h water flow at 22°C.
- Executive summary:
The water solubility of the oxypicoline sample was determined according to OECD Guideline 105 (1982) using the column elution method to be 8.7 mg/L with a 12.5 mL/h water flow at 22°C and 8.3 mg/L with a 25 mL/h water flow at 22°C.
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