Registration Dossier
Registration Dossier
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EC number: 248-433-6 | CAS number: 27375-52-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 225.802 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide in rat was estimated to be 2225.802 mg/kg of body weight. Acute oral toxicity of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide to rat indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide does not exhibits acute toxicity by the oral route.
- Executive summary:
The acute oral median lethal dose (LD50) of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide in rat was estimated to be 2225.802 mg/kg of body weight. Acute oral toxicity of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide to rat indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide does not exhibits acute toxicity by the oral route.
Reference
The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
("a" and ("b" and "c" ) )
Domain logical expression index: "a"
Similarity boundary:Target: c1(S(=O)(=O)CCO)ccc(NC(C)=O)cc1
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Parametric boundary:The target chemical should have a value of log Kow which is >= -0.907
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is <= 0.0724
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 225.802 mg/kg bw
- Quality of whole database:
- QSAR model considered reliable by OECD
Additional information
QSAR model considered reliable by OECD
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
