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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
21 Aug - 24 Aug 1962
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1962
Report date:
1962

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
Remarks:
roup-wise documentation of clinical signs was performed over the 7-day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose. The clinical signs and findings were reported in summary form.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Isobutyl acrylate
EC Number:
203-417-8
EC Name:
Isobutyl acrylate
Cas Number:
106-63-8
Molecular formula:
C7H12O2
IUPAC Name:
isobutyl acrylate
Specific details on test material used for the study:
- Name of test material: Isobutyl acrylate
- Physical state: liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 122-271 g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: aqueous emulsion with traganth
Details on oral exposure:
VEHICLE
- Amount of vehicle: 200; 1600; 3200; 4000; 5000; 6400 µL/kg bw. Calculation of concentrations (mg/kg bw) based on density of the test substance (0.89 g/mL).
Doses:
178; 1424; 2848; 3560; 4450; 5696 mg/kg bw
No. of animals per sex per dose:
5 animals/dose
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 4 895 mg/kg bw
Based on:
test mat.
Mortality:
No mortality was observed during the 7 day observation period in the 178 to 3560 mg/kg bw dose groups. One rat died within the first 24 hours in the 4450 mg/kg bw dose group. In the 5696 mg/kg bw dose group, all 5 rats died within the first 24 hours.
Clinical signs:
other: Clinical symptoms in the highest dose group were narcosis, staggering gait, apathy and abdominal position. Some animals of the other dose groups showed slight apathy after dose administration.
Gross pathology:
Kidneys were hyperemic in 4 of the sacrificed animals. No changes were observed in the deceased animals.

Any other information on results incl. tables

Dose (mg/kg bw)

No. of animals

Mortality after

1 h

24 h

48 h

7 days

5696

5

0/5

5/5

5/5

5/5

4450

5

0/5

1/5

1/5

1/5

3560

5

0/5

0/5

0/5

0/5

2848

5

0/5

0/5

0/5

0/5

1424

5

0/5

0/5

0/5

0/5

178

5

0/5

0/5

0/5

0/5

Original value reported: LD50 = 5500 µL/kg bw (corresponding to ca. 4895 mg/kg bw).

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met