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Diss Factsheets
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EC number: 215-242-4 | CAS number: 1314-80-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, guideline-comparable proprietary study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- other: Code of Federal Regulations (Part 191.1)
- GLP compliance:
- no
- Remarks:
- : study pre-dates GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Diphosphorus pentasulphide
- EC Number:
- 215-242-4
- EC Name:
- Diphosphorus pentasulphide
- Cas Number:
- 1314-80-3
- Molecular formula:
- P2S5
- IUPAC Name:
- [(disulfanylidene-λ⁵-phosphanyl)sulfanyl]-λ⁵-phosphanedithione
- Details on test material:
- The test material is described as a light yellow powder.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Sprague-Dawley albino rats of weight 160-205 g were used in this test. The animals were fasted for 24 hours prior to treatment.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Aqueous tragacanth
- Details on oral exposure:
- The test material was administered in single doses by means of a stomach tube.
- Doses:
- 215, 464, 1000 and 2150 mg/kg bw
- No. of animals per sex per dose:
- 5 male rats (body weight 160-205g) were used for each dose level
- Control animals:
- no
- Details on study design:
- The test material was administered in single doses by means of a stomach tube. Five animals were used for each dose level. The animals were fasted for 24 hours prior to treatment. The animals were observed for 14 days after treatment for mortalities and signs of toxicity.
Results and discussion
- Preliminary study:
- No preliminary study
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 791 mg/kg bw
- 95% CL:
- 467 - 1 350
- Mortality:
- At a dose level of 2150 mg/kg, all rats were found dead 6 hours after dosing. At a dose level of 464 and 1000 mg/kg, the rats that did died did so within 48 hours. For the dose levels, 464 mg/kg and 1000 mg/kg there was 2 out of 5 rats which resulted in death.
- Clinical signs:
- other: At all dose levels the rats became slightly depressed and irritable.
- Gross pathology:
- No autopsies performed.
- Other findings:
- No further findings.
Any other information on results incl. tables
Mortality in the rat
Dose level (mg/kg bw) |
|||
215 |
464 |
1000 |
2150 |
0/5 |
2/5 |
2/5 |
5/5 |
- | 0 -48h | 0 -48h | 0 -6h |
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 was calculated to be 791 (467 -1350) bw. The test substance is therefore classified as (R22) 'Harmful if swallowed' on the basis of this study.
- Executive summary:
The acute oral toxicity of the substance was investigated in fasted male rats. Five male rats were gavaged with a single dose of the test material (in aqueous gum tragacanth) at dose levels of 215, 464, 1000 and 2150 mg/kg bw and observed for 14 days.
At the 2150 mg/kg bw, dose level all rats were found dead within six hours of dosing. At all levels, the test substance caused the rats to become depressed and irritable. At 464 and 1000 mg/kg bw, 2 out of 5 rats died. The acute oral LD50 was calculated to be 791 (467 -1350) mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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