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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Draize test
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
3-aminopropan-1-ol
EC Number:
205-864-4
Cas Number:
156-87-6
Molecular formula:
C3H9NO
IUPAC Name:
3-aminopropan-1-ol

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Gaukler
- Weight at study initiation: 3.1 kg

Test system

Type of coverage:
not specified
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
other: untreated skin
Amount / concentration applied:
no data
Duration of treatment / exposure:
3 min and 1 hour
Observation period:
8 days
Number of animals:
2 animals (1 male, 1 female)
Details on study design:
no data

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24 h
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 1 hour exposure
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24 h
Score:
2
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 1 hour exposure
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
48 h
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 1 hour exposure
Irritation parameter:
edema score
Basis:
animal #1
Time point:
48 h
Score:
3
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 1 hour exposure
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 8 d
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 1 hour exposure
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 8 d
Score:
2
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 1 hour exposure
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
72 h
Remarks on result:
not measured/tested
Irritation parameter:
edema score
Basis:
animal #1
Time point:
72 h
Remarks on result:
not measured/tested
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24 h
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 1 hour exposure
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24 h
Score:
2
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 1 hour exposure
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
48 h
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 1 hour exposure
Irritation parameter:
edema score
Basis:
animal #2
Time point:
48 h
Score:
2
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 1 hour exposure
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 8 d
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 1 hour exposure
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 8 d
Score:
2
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 1 hour exposure
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
72 h
Remarks on result:
not measured/tested
Irritation parameter:
edema score
Basis:
animal #2
Time point:
72 h
Remarks on result:
not measured/tested
Irritation parameter:
erythema score
Basis:
mean
Time point:
24/48 h
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 1 hour exposure
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48 h
Score:
2.25
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 1 hour exposure

Any other information on results incl. tables

After 8 days, the erythema and edema score of both animals were 4 and 2 respectively, necrosis was observed in both animals.

A parasitic infestation of the liver was observed in both animals, which was of no relevance for this study.

 Individual readings:

Readings

Animal

Exposure period: 3 min

Erythema

Edema

Additional findings

3 min

1

2

0

 

2

2

0

spotted appearance

24 h

1

2

1

 

2

2

1

spotted appearance

48 h

1

2

0

 

2

2

1

 

72 h

1

nd

nd

 

2

nd

nd

 

8 d

1

0

0

 

2

1

0

desquamation

Mean 24, 48, 72 h

1

2

0.5

 

2

2

1

 

Mean 24, 48, 72 h

1-2

2

0.75

 

 

Readings

Animal

Exposure period: 1 hour

Erythema

Edema

Additional findings

1 h

1

2

2

spotted appearance, exceeding area of application

2

2

2

spotted appearance, exceeding area of application, soft necrosis

24 h

1

4

2

exceeding area of application, soft necrosis

2

4

2

exceeding area of application, soft necrosis

48 h

1

4

3

exceeding area of application, parchment-like necrosis

2

4

2

exceeding area of application, parchment-like necrosis

72 h

1

nd

nd

 

2

nd

nd

 

8 d

1

4

2

exceeding area of application, leather-like necrosis

2

4

2

leather-like necrosis

Mean 24, 48 h

1

4

2.5

 

2

4

2

 

Mean 24, 48 h

1-2

4

2.25

 

nd: not determined

Leather-like or hard necroses represent so-called full-thickness necroses involving all layers of the skin. Such necroses are relevant for classification representing a chemical being corrosive to the skin.

Applicant's summary and conclusion

Interpretation of results:
Category 1B (corrosive) based on GHS criteria
Conclusions:
Necrosis was observed in both animals after an exposure period of 1 hour.