Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-225-4 | CAS number: 104-67-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 84 µg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 58.5 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 8.4 µg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
- PNEC marine water (intermittent releases):
- 5.85 µg/L
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 80 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 5.341 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.534 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 1.019 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- PNEC oral
- PNEC value:
- 66.7 mg/kg food
- Assessment factor:
- 300
Additional information
Environmental fate and pathways:
The registered substance is readily biodegradable, has low mobility in soils, and is not bioaccumulable according to CLP and PBT criteria. Regarding volatilisation, it is assumed that the registered substance will volatilise slowly from water surfaces under environmental conditions.
Aquatic toxicity:
Acute and chronic data on the registered substance are available for three aquatic trophic levels: algae, aquatic invertebrates and fish and are summarised below.
- Algae: 72h-ErC50 = 7.218 mg/L; 72h-ErC10 = 1.669 mg/L.
- Aquatic invertebrates: 48h-EC50 = 5.85 mg/L; 21d-EC10 = 1.02 mg/L.
- Fish: 32d-EC10 = 0.84 mg/L.
Among all data available, the fish seems to be the most sensitive species further to chronic exposure with a 32d-EC10 value at 0.84 mg/L. As chronic data are available, the acute fish study does not need to be conducted.
To assess the toxicity of the registered substance to microorganisms a weight of evidence approach was used with four studies. The first and second studies were performed on the registered substance and no toxicity were observed. The third and fourth studies were performed on a similar substance, a linear saturated 4-hydroxycarboxylic acid derived-lactone with 10 carbons (one carbon less in the aliphatic chain than the registered/target substance). Both substances have the same mechanism of action (MechoA 2.1) and share a common basic structure. The source substance is considered adequate for read-across purpose (please refer to the RAAF document in IUCLID section 13 for detailed justification). The lowest EC50 value, determined at 800 mg/L, was chosen as key value for the chemical safety assessment of the registered substance.
Sediment toxicity:
In the absence of any ecotoxicological data for sediment-dwelling organisms, the PNECs sediment were calculated using the Equilibrium Partitioning Method (EPM). This method uses the PNEC water for aquatic organisms and the suspended matter/water partitioning coefficient as inputs. As the chemical safety assessment, based on this screening method, indicates RCR sediment lower than 1.0, no sediment toxicity tests with benthic organisms need to be done.
Terrestrial toxicity:
With a Koc value at 599.8 L/kg and a log Kow value lower than 5.0, the substance does not have a high potential to adsorb to soil. The substance is readily biodegradable so is not persistent in the environment, and is not very toxic to aquatic organisms with E(L)C50 values greater than 1.0 mg/L. Therefore, according to section R.7.11.5.3., Chapter R.7c of the ECHA Guidance on information requirements and chemical safety assessment (version 3.0, June 2017), the substance should be classed as a soil hazard category 1, and thus, the Equilibrium Partitioning Method (EPM) has been used as a screening assessment, for assessing the hazard to terrestrial organisms. As RCR soil are lower than 1.0, no toxicity testing for soil organisms need to be done.
Conclusion on classification
No existing Harmonised Classification
Self-classification:
1 mg/L < acute E(L)C50 < 10 mg/L; 0.1 mg/L < chronic EC10 < 1 mg/L; readily biodegradable; log Kow = 3.6.
The registered substance is classified as Category Chronic 3 for the environment according to the Annex VI of the Regulation (EC) No 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)