Bromine

Eye irritation

Administrative data

Endpoint:

eye irritation

Remarks:

other:

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Documentation insufficient for assessment.

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

1967

Report date:

1967

Materials and methods

Principles of method if other than guideline:

A drop of bromine was directly applied to the eye, and was washed out after 5 seconds.

Test material

Test material information

Constituent 1

Reference substance name:

Bromine

EC Number:

231-778-1

EC Name:

Bromine

Cas Number:

7726-95-6

Molecular formula:

Br2

IUPAC Name:

dibromine

Test animals / tissue source

Species:

rabbit

Strain:

not specified

Test system

Amount / concentration applied:

Drop applied

Duration of treatment / exposure:

5 seconds

Observation period (in vivo):

1 minute and thereafter

Results and discussion

In vivo

Results

Irritation parameter:

other:

Time point:

other: less than one minute

Remarks on result:

other: Cornea opaque where drop hit

Irritant / corrosive response data:

Even with washout in 5 seconds, animals showed severe initial pain with marked tissue necrosis in less than one minute. Cornea was observed to be opaque where drop hit. Probable permanent corneal damage and impairment of vision. Bromine and bromine chloride data were the same.

Applicant's summary and conclusion

Interpretation of results:

corrosive

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

Bromine liquid is corrosive to eye tissues, even with 5 second washout. Damage is likely to be permanent.

Executive summary:

Bromine liquid was corrosive to rabbit eyes when applied neat with 5 second washout.