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Diss Factsheets
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EC number: 203-692-4 | CAS number: 109-66-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- behavioural effects
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable with restrictions because there are no statements indicating if the study was conducted according to GLPs or other accepted guidelines.
Data source
Reference
- Reference Type:
- publication
- Title:
- Behavioral toxicology of volatile organic solvents v. comparisons of the behavioral and neuroendocrine effects among n-alkanes
- Author:
- Glowa, J.R.
- Year:
- 1 991
- Bibliographic source:
- Journal of the American College of Toxicology 10(6):639-646
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test substance was tested for its ability to impair performance and stimulate hypothalamic-pituitary activity in mice. Performance was assessed using operant responding maintained under a fixed interval 60-sec schedule of milk presentation. Exposure duration was based on time the mice needed to complete the milk-presentation series. Cumulative concentration-effect functions for the test substance were obtained by incrementally increasing exposure concentrations until responding was abolished. Recovery from these rate-decreasing effects was determined 30 min after exposure to the highest concentration.
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- neurotoxicity
Test material
- Reference substance name:
- Pentane
- EC Number:
- 203-692-4
- EC Name:
- Pentane
- Cas Number:
- 109-66-0
- Molecular formula:
- C5H12
- IUPAC Name:
- pentane
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- male
Results and discussion
- Details on results:
- Concentrations of less than 10,000 ppm n-pentane slightly increased responding. Larger concentrations decreased responding in a concentration-related manner, with 30,000 and 56,000 ppm decreasing responding approximately 50% and 100%, respectively. Responding recovered fully 30 min following the removal of 56,000 ppm pentane. Serum adrenocorticotropin hormone (ACTH) levels increased in a dose-dependent manner; ACTH release is related to hypothalamic-pituitary axis activity. The concentration expected to decrease responding 10% In 1 out of 10, 1 out of 100, and 1 out of 1000 such experiments was calculated to be 10,226; 4057; and 1429, respectively, and the mean (In) concentration to result in a 50% (EC50) and 10% (EC10) decrement in responding was 36,130 +/- 9531 and 26,553 +/- 12,980, respectively.
Applicant's summary and conclusion
- Conclusions:
- Concentrations of less than 10,000 ppm n-pentane slightly increased responding. Larger concentrations decreased responding in a concentration-related manner, with 30,000 and 56,000 ppm decreasing responding approximately 50% and 100%, respectively. Responding recovered fully 30 min following the removal of 56,000 ppm pentane. Serum adrenocorticotropin hormone (ACTH) levels increased in a dose-dependent manner; ACTH release is related to hypothalamic-pituitary axis activity. The concentration expected to decrease responding 10% In 1 out of 10, 1 out of 100, and 1 out of 1000 such experiments was calculated to be 10,226; 4057; and 1429, respectively, and the mean (In) concentration to result in a 50% (EC50) and 10% (EC10) decrement in responding was 36,130 +/- 9531 and 26,553 +/- 12,980, respectively.
- Executive summary:
In a neurotoxicity study, n-pentane was administered to 8 adult male CD-1 mice/concentration by dynamic whole body exposure at five concentrations, in order to assess the effect of the test substance on response time.
No mortality or signs of systemic toxicity were reported. The LOAEC and NOAEC were not reported. The concentration expected to decrease responding 10% In 1 out of 10, 1 out of 100, and 1 out of 1000 such experiments was calculated to be 10,226; 4057; and 1429, respectively, and the mean (In) concentration to result in a 50% (EC50) and 10% (EC10) decrement in responding was 36,130 +/- 9531 and 26,553 +/- 12,980, respectively.
This study received a Klimisch score of 2 and is classified as reliable with restrictions because there are no statements indicating if the study was conducted according to GLPs or other accepted guidelines.
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