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Diss Factsheets
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EC number: 946-573-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 10 August to 1 September 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The study was conducted according to an internationally recognised method, and under GLP. The substance is considered to be adequately characterised. Therefore full validation applies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- 2008
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- GLP compliance programme (inspected on 13-14 October 2014 / signed on 8 April 2015)
- Type of method:
- capillary method
- Key result
- Melting / freezing pt.:
- >= 50.9 - <= 56.1 °C
- Remarks on result:
- other: main of 2 determinations with capillary method
- Conclusions:
- The melting range was determined as 50.9°C to 56.1 °C (324.1K to 329.3 K).
- Executive summary:
The melting point test with the substance was performed under GLP according to OECD 102 / EU A1 guideline,using capillary method.
At first one experiment was conducted via DSC (differential scanning calorimetry). As no significant events were observed, the capillary method was conducted as a main test. The melting range was determined as 50.9°C to 56.1 °C (324.1K to 329.3 K) with capillary method. These values are the means from two independent determinations.
Reference
RESULTS
Different methods were performed to determine the melting point of this substance: DSC and capillary method pre-tests. Then capillary method as a main test was chosen.
Pre-test for melting range following capillary method
Table 4.2.1.- Values Pre-Test for melting range following capillary method
Begin of melting process |
End of melting process |
50.8 °C |
54.2°C |
The test item melted to a yellow to red-brown liquid. After cooling down the test item returned solid visually looked like the original state.
Security Pre-test for the DSC instrument
Thecrucible was found visually unchanged after reaching a temperature of 420°C. The weight was recorded with 47.31mg (1.15 mg residue after 420°C). After further heating to 600°C and cooling down the crucible was found visually unchanged as well. The weight was recorded with 46.68 mg (0.52 mg residue after 600°C). After heating and weighing of 600 °C the crucible was opened, a black residue (like charcoal) was visible.
Calibration
After calibration with indium and zinc the measurement of indium yielded the following values:
Table 4.2.2.-Values DSC Indium
ExpectedMelting point |
Measured Melting point |
Expected Energy |
Measured Energy |
Assessment |
156.6 ± 1.0°C |
156.73 °C |
28.45 ± 1.0 J/g |
28.57 J/g |
OK |
The measurement of indium after calibration met the validity criteria.
Results with DSC method
Observations
Table 4.2.3.- Values Observations
Mass test item |
Mass crucible (before measurement): |
Mass crucible (after measurement): |
Observations |
|
First Measurement |
3.23 mg |
49.02 mg |
48.94 mg |
After the test the crucible was visually unchanged, the crucible was opened and a red-brown glassy mass was visible |
DSC measurements show no events, for that raison Melting Point with the Capillary Method was performed.
Results Melting Point with the Capillary Method (main test)
Table 4.2.4.- Values Melting Point with the Capillary Method
Melting point/range |
Begin |
End |
First Determination |
50.8 °C (324.0 K) |
56.0 °C (329.2 K) |
Second Determination |
50.9 °C (324.1 K) |
56.1 °C (239.3 K) |
The test item melted to a yellow to red-brown viscous liquid. After cooling down the test item returned solid looked like the original state.
Melting range: 50.9 °C to 56.1 °C (324.1 K to 329.3 K)
Standard deviation: 0.07 (begin); 0.07 (end)
Estimated accuracy: ± 0.1 °C
Validity melting point
All validity criteria are presented in the following table.
Table 4.2.5.- Validity melting point
Parameter |
Criterion |
Found |
Assessment |
Difference between duplicate determinations |
<=0.5 K |
0.1 K |
valid |
Difference between begin and end of melting process |
<=0.5 K |
5.2 K |
melting range is stated |
The validity criterion “difference between duplicate determinations” was met. The test item showed a melting range, no melting point. As the test item consists of a mixture, this is considered as normal.
Description of key information
The melting range was determined as 50.9°C to 56.1 °C (324.1K to 329.3 K).
Key value for chemical safety assessment
Additional information
A reliable GLP experimental study, conducted according to a recognized OECD/EC guidelines using capillary method, is available.
It is considered as a key study. The result is retained as key data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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