Registration Dossier
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EC number: 419-050-3 | CAS number: 79944-37-9 AMINODIOXEPAN
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 Jan - 23 Mar 1993
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Version / remarks:
- 84/449
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- gas chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- -0.83
- Temp.:
- 25 °C
- pH:
- 10
- Type:
- Pow
- Partition coefficient:
- 0.149
- Temp.:
- 25 °C
- pH:
- 10
- Details on results:
- 95% confidence interval - 0.81 to -0.845
- Conclusions:
- The partition coefficient of test substance was determined with, log Pow = -0.83.
- Executive summary:
The study was performed to assess the partition coefficient. The study was conducted in accordance with EEC Method for "determination of the partition coefficient", Directive 84/449/EEC, method A.8. The partition coefficient of test substance was determined with, log Pow = -0.83.
Reference
Validity criteria for the measurement of the partition coefficient:
| Target condition according to guideline: | Actual condition according to the study: | Validity criteria met: |
| In order to assure the accuracy of the partition coefficient, duplicate determinations are to be made under three different test conditions, whereby the quantity of substance specified as well as the ratio of the solvent volumes may be varied. The determined values of the partition coefficient expressed as their common logarithms should fall within a range of ± 0,3 log units. | The partition coefficent of the test substance was determined under three differnt volumen ratios. The single values of the measurements were not reported. However, mean values of the partition coefficent expressed as common logarithms vary < 0.01 log units. Therefore, accuracy of the determined value are considered as sufficient. | yes |
Description of key information
The study was performed to assess the partition coefficient. The study was conducted in accordance with EEC Method for "determination of the partition coefficient", Directive 84/449/EEC, method A.8. The partition coefficient of test substance was determined with, log Pow = -0.83.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.83
Additional information
The temperature is not specified.
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