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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 245-629-3 | CAS number: 23386-52-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Endpoint summary
Administrative data
Description of key information
9.33 L/kg
Additional information
In accordance with EC 1907/2006, Annex IX, point 9.3.2, column 2, bioaccumulation in aquatic species (water and sediment) is not required due to the fact that the substance has a log Kow of < 3 (-1.504).
An experimental study with a structurally similar source substance (CAS 577-11-7, Arnot & Gobas 2006, 42 day exposure, steady state) resulted in a BCF of 9.33 L/kg in carp (4.1% lipid content). A further 72 -hour study with the same source substance CAS 577-11-7 (Goodrich et al. 1991) with rainbow trout resulted in a BCF of 3.78 L/kg in carcas. In addition to the experimental results, a QSAR using the BCFBAF (v3.01) module implemented in EPISuite 4.11 resulted in a BCF of 56.2 L/kg for the source substance. Hence, there was a good agreement between the experimental values and the QSAR with the indication that the result from the QSAR model results in more conservative values. For the registered substance, the same QSAR model as for the source substance resulted in a BCF of 3.16 L/kg. Hence, it can be assumed that the EPISuite result is conservative for the registered substance as well.
For the registered substance, a QSAR calculation with the model Catalogic resulted in a maximum BCF of 4.79 L/kg for the parent substance and its metabolites. As for EPISuite, a direct comparison of the experimental result and the Catalogic QSAR prediction for the BCF of docusate sodium, the source substance, resulted in the finding that the QSAR prediction from Catalogic for docusate sodium and its metabolites (13.8 L/kg) is slightly more conservative than the experimental finding (9.33 L/kg). Hence, it can be assumed that this is the case also for the registered substance.
For the risk assessment, the more conservative experimentally determined BCF of 9.33 L/kg will be used since this study with the source substance is considered to be scientifically most relevant study. The use of the less conservative QSAR result of the source substance would not have had a different qualitative outcome for, e.g., the PBT assessment. The QSAR results (two models) for the registered substances and its metabolites resulted in lower BCFs. Hence, the BCF of 9.33 L/kg is conservative and will be used for the risk assessment.
In conclusion, bioaccumulation of the substance is of no concern.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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