Registration Dossier
Registration Dossier
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EC number: 205-992-0 | CAS number: 274-09-9
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: predates implementation of GLP and/or development of study guidelines, restrictions in reporting, acceptable with restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 965
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Two groups of Swiss mice were treated with daily doses of 250 and 500 mg/kg for 60 days. Mortality and toxic signs were recorded.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 1,3-benzodioxolane
- EC Number:
- 205-992-0
- EC Name:
- 1,3-benzodioxolane
- Cas Number:
- 274-09-9
- Molecular formula:
- C7H6O2
- IUPAC Name:
- 2H-1,3-benzodioxole
- Details on test material:
- - Name of test material: methylenedioxybenzene
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
Administration / exposure
- Route of administration:
- oral: unspecified
- Duration of treatment / exposure:
- 60 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
250 and 500 mg/kg
Basis:
no data
Examinations
- Observations and examinations performed and frequency:
- Mortality and toxic signs were recorded.
Results and discussion
Results of examinations
- Details on results:
- At daily doses of 500 mg/kg methylenedioxybenzene the percentage mortality was 81%, 250 mg/kg/daily resulted in mortality of 73%. Methylenedioxybenzene produced both stimulation and depression.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- At daily doses of 500 mg/kg and 250 mg/kg methylenedioxybenzene for 60 days, the mortality was 81% and 73%, respectively.
- Executive summary:
Two groups of Swiss mice were treated with daily doses of 250 and 500 mg/kg for 60 days. Mortality and clinical signs were recorded. At daily doses of 500 mg/kg methylenedioxybenzene the percentage mortality was 81%, 250 mg/kg/daily resulted in a mortality of 73%. Methylenedioxybenzene produced both stimulation and depression.
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