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EC number: 228-846-8 | CAS number: 6362-80-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted according to GLP and guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,1'-(1,1-dimethyl-3-methylene-1,3-propanediyl)bisbenzene
- EC Number:
- 228-846-8
- EC Name:
- 1,1'-(1,1-dimethyl-3-methylene-1,3-propanediyl)bisbenzene
- Cas Number:
- 6362-80-7
- Molecular formula:
- C18H20
- IUPAC Name:
- (4-methyl-4-phenylpent-1-en-2-yl)benzene
- Details on test material:
- - Physical state: Liquid
- Analytical purity: 2,4-dIphenyl-4-methyl-1-pentene 92% min; 2,4-dIphenyl-4-methyl-2-pentene 5% max
- Lot/batch No.: 1102
- Storage condition of test material: Room temperature in the dark
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ranch Rabbits Ltd., Crawley Down, Sussex, England
- Age at study initiation: Approximately 11 to 13 weeks
- Weight at study initiation: 2.6 to 2.9 kg
- Housing: Housed individually in metal cages with perforated floors
- Diet: SDS Stanrab (P) rabbit diet ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature: 19°C
- Humidity: 30-70 %
- Air changes: Approximately 19 per hr
- Photoperiod: 12 hours artificial light (0700 - 1900 hours) in each 24 hour period
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 14 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: Dorso-lumbar region
- Type of wrap if used: Elastoplast elastic adhesive dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Washed with water
- Time after start of exposure: 4 hr
SCORING SYSTEM: Grading and scoring of dermal reactions were performed using the prescribed numerical scoring system as follows:
Erythema and eschar formation:
No erythema 0
Very slight erythema (barely perceptible) 1
Well defined erythema 2
Moderate to severe erythema 3
Severe erythema (beet redness) to slight
eschar formation (injuries in depth) 4
Oedema formation:
No oedema 0
Very slight oedema (barely perceptible) 1
Slight oedema (edges of area well defined by
definitive raising) 2
Moderate oedema (raised approximately 1 millimetre) 3
Severe oedema (raised more than 1 millimetere
and extending beyond the area of exposure) 4
Any other lesion not covered by this scoring system, was described
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Remarks on result:
- other: Necrosis observed on day 4, but was ameliorated by day 9
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 11 days
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Irritant / corrosive response data:
- The numerical scores awared to the dermal reactions are given in table 1.
Well defined erythema with slight oedema was evident at all three treatment sites following the removal of the dressings (day 1)
Similar reactions persisted for a further 5 or 7 days before regressing in two animals, but progressed in the remaining animal by day 4 into necrotic foci with very slight or slight oedema.
Reactions ameliorated at all sites by days 7 or 9 with very slight erythema and oedema present. A similar level of response (with or without very slight oedema) persisted, but resolved by day 14.
Desquamation of the stratum corneum (sloughing) was seen in all animals by days 6/9 and was still visible at all sites on day 14.
Any other information on results incl. tables
Table 1: Dermal reactions elicited by the test substance
Rabbit number and sex |
E=erythema O=oedema |
Day |
|||||||||||||
1* |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
||
866♀ |
E O |
2 1 |
2 1 |
2 1 |
2 1 |
2 1 |
2B 1 |
1B 1 |
1B 1 |
1B 1 |
1B 0 |
1B 0 |
1B 0 |
1B 0 |
0B 0 |
867♀ |
E O |
2 1 |
2 1 |
2 1 |
2 1 |
2 1 |
2B 1 |
2B 1 |
2B 1 |
1B 1 |
1B 1 |
1B 0 |
1B 0 |
1B 0 |
0B 0 |
868♀ |
E O |
2 1 |
2 1 |
2 1 |
4A 2 |
4A 2 |
4A 1 |
4A 1 |
4A 1 |
1B 1 |
1B 0 |
1B 0 |
1B 0 |
1B 0 |
0B 0 |
* Approximately 30 minutes after removal of the dressing
A Necrosis
B Sloughing
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified as irritating to skin under CLP
- Conclusions:
- The test substance is not considered to be irritating to skin according to CLP Regulation (EC) no. 1272/2008
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