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Diss Factsheets
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EC number: 215-114-8 | CAS number: 1303-00-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
There exist the following mutagenicity studies with full reliability:
- in-vitro gene mutation in bacteria (Zeiger et al. 1992),
- in-vitro gene mutation in mammalian cells (Stone, 2010) and the
- in-vivo micronucleus test (NTP, 2000).
The in-vitro micronucleus test (Gibson et al. 1997) has also a sufficient but no full reliability.
Not sufficiently reliable are the sudies of Kerckaert et al. (1996), cell transformation test in SHE cells, and of Duerksen-Hughes et al. (1999), p53 induction in vitro. They used no standard study protocol and the specificity and selectivity of their test system has not been proven sufficiently reliable, therefore these 2 studies are ignored.
Husgavfel-Pursiainen et al. (1990) published results from a sister-chromatid exchange study and a chromosome aberration study in GaAs exposed CHO cells. Both studies showed negative results. However, these studies were considered as not assignable and could not be evaluated for their reliability due to availability as abstracts only.
The studies with sufficient reliability are negative and clearly show that GaAs is not mutagenic or genotoxic.
Short description of key information:
The following mutagenicity studies with sufficient reliability are available: in-vitro gene mutation in bacteria (Zeiger et al. 1992), in-vitro micronucleus test (Gibson et al. 1997), in-vitro gene mutation in mammalian cells (Stone, 2010) and in-vivo micronucleus test (NTP, 2000).
All study results are negative for the respective endpoints. In conclusion, the results of these studies clearly show that GaAs is not mutagenic or genotoxic. A classification with regard to genotoxicity is not required.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Results of the studies with sufficient reliability are negative and clearly show that GaAs has no genotoxic or mutagenic effects.
Therefore a classification according to CLP regulation and subsequent regulations with regard to mutagenicity or genotoxicity is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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