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Diss Factsheets
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EC number: 203-571-6 | CAS number: 108-31-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
In a two-generation reproductive toxicity study, rats were dosed via gavage to 0, 20, 55 and 150 mg/kg/day maleic anhydride. The NOAEL for reproductive effects is 55 mg/kg/day (highest dose tested due to parental death at 150 mg/kg/day.) However, in the parental group adverse effects (mortality, body weight changes, and respiratory irritation) were observed at 150 mg/kg/day (the highest dose tested.) In addition, there were histopathological effects in the kidneys and bladder of the parental animals (first generation only) in all treated dose groups. The LOAEL for parental effects is 20 mg/kg/day.
Short description of key information:
NOAEL=55 mg/kg/day for reproductive effects in rat.
NOAEL=20 mg/kg/day for parental effects in rat.
Effects on developmental toxicity
Description of key information
NOAEL=140 mg/kg/day for developmental toxicity in rat.
Additional information
No developmental toxicity was observed when pregnant rats were dosed with maleic anhydride via gavage to 0, 30, 90 and 140 mg/kg/day. The dams in all dose groups either lost weight or failed to gain weight between days 6 and 9 of gestation; however, this effect was not statistically significant at any interval and was reversible. As a result, the NOAEL (maternal) was determined to be 140 mg/kg/day.
Justification for classification or non-classification
According to Directive 67/548/EEC, no classification is proposed for this substance.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.