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Diss Factsheets
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EC number: 234-319-3 | CAS number: 11097-59-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Dissociation constant
Administrative data
Link to relevant study record(s)
Description of key information
Study technically not feasible.
Key value for chemical safety assessment
Additional information
Methods used to determine dissociation constants are the spectrophotometric, titration and calculation methods.
The test substance is a complex mixture of metal hydroxide hydrates present at varying degrees.
Based on a study with Magnesium-aluminium-hydroxide-carbonate, the water solubility of the test substance at neutral pH was determined, to be <0.009 mg/l. Since for the determination of the dissociation constants a test concentration lower than half of the water solubility has to be used, a test concentration of < 0.0045 mg/l should be selected.
The spectrophotometric method relies on the use of pure substances to be able to differentiate between the ionized and non-ionized species of the test substance. Due to the complexity of the test substance in combination with its low water solubility and lack of
UV-activity, the spectrophotometric method cannot be applied.
The use of an alternative method such as titration can also not be considered as this is a less sensitive method than the spectrophotometric method and not generate reliable results given the insolubility of the test substance in distilled water.
The conductometric method cannot be applied either due to the complex nature of the substance in combination with its insolubility in water.
As an alternative, calculation of the pKa values for the major components from their structures using Perrin's calculation method could be considered. However, the molecular structures of the test substance contain metal ions (a.o. coordination complexes) which cannot be computed using the mentioned computer program and would not be supported by the calculation algorithms.
Conclusion:
It was not possible to determine the pKa values of Magnesium-aluminium-hydroxide-carbonate
experimentally. Also, due to the complexity and nature of the test substance, it was not possible to calculate the pKa values using the pKalc version 5.0 computer program. Therefore, pKa values for[carbonato(2-)]hexadecahydroxybis(aluminium)hexamagnesium cannot be given.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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