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Diss Factsheets
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EC number: 264-727-7 | CAS number: 64194-22-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Carcinogenicity
Administrative data
Description of key information
No experimental testing and no human data on carcinogenicity are available on 3-methyl-1.5-pentanediol diacrylate.
A 90-day repeated toxicity study, performed on 3-methyl-1.5-pentanediol diacrylate, no target organ was identified leading to the classification as STOT RE. Moreover, no adverse histological changes were observed, including pre-neoplastic changes (hyperplasia or metaplasia). Moreover, 3-methyl-1.5-pentanediol diacrylate is not genotoxic: all three in vitro mutagenicity studies (bacterial reverse mutation test, in vitro mammalian cell gene mutation test, in vitro micronucleus test) were negative.
So, based on the available experimental data, 3-methyl-1.5-pentanediol diacrylate is not considered as carcinogen.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
According to the ECHA guidance R7A (V.5, 2016), “Carcinogens may be identified from epidemiological studies, from animal experiments and/or other appropriate means that may include (Quantitative) Structure-Activity Relationships ((Q)SAR) analyses and/or extrapolation from structurally similar substances (read-across).” and “The determination of the carcinogenic potential of a chemical is based on a Weight of Evidence approach”.
First of all, no experimental testing and no human data on carcinogenicity are available on 3-methyl-1.5-pentanediol diacrylate.
A 90-day repeated toxicity study was performed on 3-methyl-1.5-pentanediol diacrylate. This type of test can identify tissues that may be specific targets for toxicity and subsequent carcinogen effects. In this study, no target organ was identified leading to the classification as STOT RE. Moreover, no adverse histological changes were observed, including pre-neoplastic changes (hyperplasia or metaplasia).
Then, 3-methyl-1.5-pentanediol diacrylate is not genotoxic. A great deal of information concerning the possible carcinogenicity of a compound can be obtained from a battery of short-term mutagenicity assays (Bridges, 1976). All three in vitro mutagenicity studies (bacterial reverse mutation test, in vitro mammalian cell gene mutation test, in vitro micronucleus test) were performed on 3-methyl-1.5-pentanediol diacrylate and are negative, meaning that 3-methyl-1.5-pentanediol diacrylate did not induce gene mutations or structural and numerical chromosome aberrations in the in vitro models.
So, based on the available experimental data, 3-methyl-1.5-pentanediol diacrylate is not considered as carcinogen.
(Q)SAR models attempt to predict the carcinogenic hazard of diverse groups of substances. Some of (Q)SAR were used to identify a potential hazard for carcinogenicity of 3-methyl-1.5-pentanediol diacrylate (OECD QSAR TOOLBOX, OncoLogic, TOX TREE, VEGA, Danish EPA (Q)SAR database, Lazar). The results of these (Q)SAR are discussed later in the attached document (in section 13 of the IUCLID). At the end, no relevant positive prediction was found for 3-methyl-1.5-pentanediol diacrylate due to the lack of information on the tools or due to the limitations of using the tools.
Based on the available QSAR, no relevant prediction allow to consider that 3-methyl-1.5-pentanediol diacrylate could be carcinogen.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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