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Diss Factsheets
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EC number: 947-662-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- For justification please refer to Read Across Justification in IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Reference
Description of key information
The acute toxicity of the read across substance Reaction products of γ-butyrolactone, naphthalene-1,6-diol and phthalic anhydride (EC 946-798-2) to aquatic invertebrates was determined according OECD 202 under GLP conditions. The 48-h EL 50 was determined to be > 100.0 mg/L.
Key value for chemical safety assessment
Additional information
No data on toxicity to aquatic invertebrates were available for the substance itself. Therefore, a read across to the close structural analogue Reaction products ofγ-butyrolactone, naphthalene-1,6-diol and phthalic anhydride (EC 946-798-2) was conducted.
Key study
To assess the toxicity of the close structural analogue (EC 946-798-2) to Daphnia magna (STRAUS), an Acute Toxicity Test according to OECD Guideline 202 was carried out in compliance with GLP principles (BASF SE, 2017). The test was conducted under semi-static conditions over a period of 48 hours with the only (limit) concentration of 100 mg/L. In addition, a negative control (without the test item) and a positive control with the reference substance potassium dichromate was performed. Since the test item is a mixture which has a low water solubility, a Water Soluble Fraction (WSF) was prepared. The WSF and the negative control were analytically verified via UPLC-MS/MS in fresh media at the start of the exposure and at renewal (0 and 24 hours) as well as in 24-hours old media at renewal and at the end of the test (24 and 48 hours). The measured concentrations of the test item were 0.0356 and 0.0421 mg test item/L in fresh media (0 and 24 hours) and 0.0187 and 0.0335 mg test item/L in 24-hour old media (24 and 48 hours). Twenty daphnids (divided into 4 replicates with 5 daphnids each) were exposed to the WSF of the test item and the control. Since the close structural analogue contains a large proportion of unidentified by-components, it was treated as a mixture and the results are based on loadings rather than on mean measured concentrations. All effect values are given based on the nominal loading of the test item of 100 mg/L. In result, at the WSF with a nominal loading of 100 mg/L of the test item, no effects on Daphnia magna were observed. Therefore, the 48-h EL50 of the close structural analogue is considered to be > 100 mg/L. The validity criteria of the test guideline were fulfilled.
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