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EC number: 237-360-5 | CAS number: 13762-51-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: United Nations and US Department of Transportation Packing Group Classification guidelines for Class 8 materials
- GLP compliance:
- yes
Test material
- Reference substance name:
- Sodium tetrahydroborate
- EC Number:
- 241-004-4
- EC Name:
- Sodium tetrahydroborate
- Cas Number:
- 16940-66-2
- Molecular formula:
- BH4.Na
- IUPAC Name:
- Sodium tetrahydridoborate(1–)
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): 15% sodium borohydride in dimethyl acetamide
- Physical state: liquid
- Lot/batch No.: MLK-58-9; TD No. 01-002
- Name of test material (as cited in study report): 15% sodium borohydride in N-methyl pyrrolidone
- Physical state: liquid
- Lot/batch No.: MLK-58-10; TD No. 01-003
- Name of test material (as cited in study report): 7.5% sodium borohydride in tri(ethylene glycol) dimethyl ether
- Physical state: liquid
- Lot/batch No.: MLK-58-14; TD No. 01-004
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: as received in solvent
- Controls:
- not specified
- Duration of treatment / exposure:
- 4-hour, 1-hour, 3 minute
- Observation period:
- 72-hours after patch removal
- Number of animals:
- 12
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: score for all solvents tested after an exposure time of at least 1 h to the test material
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: score for all solvents tested after an exposure time of at least 1 h to the test material
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- 00 -27286
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- 00 -27295
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- 00 -27296
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Remarks:
- 0 -27298
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- 00 -27286
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- 00 -27295
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- 00 -27296
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Remarks:
- 00 -27298
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
Any other information on results incl. tables
15% Sodium borohydride in dimethyl acetamide- 4 hour exposure
Erythema | Time after patch removal |
|||
Animal number | 1 hr | 24 hr | 48 hr | 72 hr |
00 -27286 | 4 blanching; green/black | 4 concave eschar | 4 concave eschar | 4 concave eschar |
Edema | ||||
Animal number | 1 hr | 24 hr | 48 hr | 72 hr |
00 -27286 | 4 pocketing edema | 4 pocketing edema | 4 pocketing edema | 4 pocketing edema |
15% Sodium borohydride in dimethyl acetamide- 1 hour exposure
Erythema | Time after patch removal |
|||
Animal number | 1 hr | 24 hr | 48 hr | 72 hr |
00 -27295 | 4 dlanching; darkened areas | 4 pocketing edema; blanching; darkened areas; concave eschar | 4 blanching; darkened areas; concave eschar | 4 blanching; darkened areas; concave eschar |
Edema | ||||
Animal number | 1 hr | 24 hr | 48 hr | 72 hr |
00 -27295 | 4 pocketing edema | 4 pocketing edema | 4 pocketing edema | 4 pocketing edema |
15% Sodium borohydride in dimethyl acetamide- 3 min exposure
Erythema | Time after patch removal |
|||
Animal number | 1 hr | 24 hr | 48 hr | 72 hr |
00 -27295 | 0 | 0 | 0 | 0 |
01 -27127 | 0 | 1 | 0 | 0 |
01 -27149 | 1 | 1 | 1 | 0 |
Edema | ||||
Animal number | 1 hr | 24 hr | 48 hr | 72 hr |
00 -27295 | 0 | 0 | 0 | 0 |
01 -27127 | 0 | 0 | 0 | 0 |
01 -27149 | 0 | 0 | 0 | 0 |
15% Sodium borohydride in N-methyl pyrrolidone- 4 hour exposure
Erythema | Time after patch removal | |||
Animal number | 1 hr | 24 hr | 48 hr | 72 hr |
00 -27296 | 4 blanching; green/black | 4 concave eschar | 4 concave eschar | 4 concave eschar |
Edema | ||||
Animal number | 1 hr | 24 hr | 48 hr | 72 hr |
00 -27296 | 4 pocketing edema | 4 pocketing edema | 4 pocketing edema | 4 pocketing edema |
15% Sodium borohydride in N-methyl pyrrolidone- 1 hour exposure
Erythema | Time after patch removal | |||
Animal number | 1 hr | 24 hr | 48 hr | 72 hr |
00-27295 | 4 blanching; darkened areas | 4 concave eschar | 4 darkened areas; concave eschar | 4 darkened areas; concave eschar |
Edema | ||||
Animal number | 1 hr | 24 hr | 48 hr | 72 hr |
00 -27295 | 4 | 4 pocketing edema | 4 pocketing edema | 4 pocketing edema |
15% Sodium borohydride in N-methyl pyrrolidone- 3 min exposure
Erythema | Time after patch removal | |||
Animal number | 1 hr | 24 hr | 48 hr | 72 hr |
01 -27132 | 0 | 0 | 0 | 0 |
01 -27142 | 1 | 1 | 1 | 0 |
01 -27159 | 0 | 0 | 0 | 0 |
Edema | ||||
Animal number | 1 hr | 24 hr | 48 hr | 72 hr |
01 -27132 | 0 | 0 | 0 | 0 |
01 -27142 | 0 | 0 | 0 | 0 |
01 -27159 | 0 | 0 | 0 | 0 |
7.5% Sodium borohydride in tri(ethylene glycol) dimethyl ether- 4 hour exposure
Erythema | Time after patch removal | |||
Animal number | 1 hr | 24 hr | 48 hr | 72 hr |
00 -27298 | 4 blanching; green/black | 4 concave eschar | 4 concave eschar | 4 concave eschar |
Edema | ||||
Animal number | 1 hr | 24 hr | 48 hr | 72 hr |
00 -27298 | 4 pocketing edema | 4 pocketing edema | 4 pocketing edema | 4 pocketing edema |
7.5% Sodium borohydride in tri(ethylene glycol) dimethyl ether- 1 hour exposure
Erythema | Time after patch removal | |||
Animal number | 1 hr | 24 hr | 48 hr | 72 hr |
00 -27295 | 4 blanching; darkened areas | 4 blanching; darkened areas; concave eschar | 4 darkened areas; concave eschar | 4 blanching; darkened areas; concave eschar |
Edema | ||||
Animal number | 1 hr | 24 hr | 48 hr | 72 hr |
00 -27295 | 4 pocketing edema | 4 pocketing edema | 4 pocketing edema | 4 pocketing edema |
7.5% Sodium borohydride in tri(ethylene glycol) dimethyl ether- 3 min exposure
Erythema | Time after patch removal | |||
Animal number | 1 hr | 24 hr | 48 hr | 72 hr |
00 -27297 | 0 | 0 | 0 | 0 |
01 -27165 | 1 | 2 | 2 | 1 |
01 -27147 | 1 | 1 | 1 | 0 |
Edema | ||||
Animal number | 1 hr | 24 hr | 48 hr | 72 hr |
00 -27297 | 0 | 0 | 0 | 0 |
01 -27165 | 0 | 0 | 0 | 0 |
01 -27147 | 0 | 0 | 0 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- Corrosive findings were evident at 4 hours.
Based on United Nations and United States Department of Transportation Packing Group classification criteria for Class 8 materials, each test material would be assigned to Packing Group II: full thickness destruction on intact skin tissue within an observation period up to 14 days starting after an exposure time of more than 3 minutes, but not more than 60 minutes).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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