Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 825-815-6 | CAS number: 227025-12-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in chemico
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- ecperimental start/end date: 14/03/2018 - 17/03/2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 442C (In Chemico Skin Sensitisation: Direct Peptide Reactivity Assay (DPRA))
- Deviations:
- no
- GLP compliance:
- yes
- Type of study:
- direct peptide reactivity assay (DPRA)
Test material
- Reference substance name:
- Hydrolyzed Quinoa
- EC Number:
- 825-815-6
- Cas Number:
- 227025-12-9
- IUPAC Name:
- Hydrolyzed Quinoa
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- Water
- Test material form:
- liquid
- Details on test material:
- dark clear liquid
Constituent 1
Constituent 2
Results and discussion
In vitro / in chemico
Resultsopen allclose all
- Key result
- Run / experiment:
- other: cysteine peptide
- Parameter:
- other: Peptide depletion [%]
- Value:
- 1.41
- Key result
- Run / experiment:
- other: lysyne peptide
- Parameter:
- other: Peptide depletion [%]
- Value:
- 11.32
- Other effects / acceptance of results:
- It was noticed that analysis of product dissolved in water (without peptide) showed signals at retention time close to cysteine peptide standard. UV spectrum for this peak is different than for cysteine peptide standard. There was no signals for buffer.
UV spectra obtained may suggest that co-elution occurs.
Nevertheless, a series of analyzes has been carried out and the results are presented above. However, the result for cysteine should be regarded as doubtful.
Such situation was not observed for lysine peptide
Also, it should be taken into account that the tested product was not completely dissolved which may affect the final result.
Any other information on results incl. tables
18E0447-1PL |
Peptide depletion [%] |
|
cysteine peptide |
lysyne peptide |
|
1.41 |
11.32 |
6. CONCLUSION
18E0447-1PL |
Peptide |
Reactivity Class |
DPRA Prediction |
Cysteine |
No or minimal reactivity |
Negative |
|
Lysyne |
Low reactivity |
Positive |
DPRA prediction for the tested product is positive.
Applicant's summary and conclusion
- Conclusions:
- It was noticed that analysis of product dissolved in water (without peptide) showed signals at retention time close to cysteine peptide standard. UV spectrum for this peak is different than for cysteine peptide standard. There was no signals for buffer.
UV spectra obtained may suggest that co-elution occurs.
Nevertheless, a series of analyzes has been carried out and the results are presented above. However, the result for cysteine should be regarded as doubtful.
Such situation was not observed for lysine peptide
Also, it should be taken into account that the tested product was not completely dissolved which may affect the final result.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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