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EC number: 287-090-7 | CAS number: 85409-23-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: dermal
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 26, 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Test material form:
- liquid: viscous
- Remarks:
- Clear water-white viscous liquid
Constituent 1
- Specific details on test material used for the study:
- Test material: (Alkyl(C12-C18)dimethylethylbenzylammonium chloride as a.i.) in aqueous solution
Lot/Batch number: Notebook #1607-3684; Sample #676-09/L
Study no: 7677-7
Description: Clear water-white viscous liquid
Purity: 50% w/w a.i.
Stability: The a.i., ADEBAC, is hydrolytically and photolytically stable under the conditions of this study and its related quaternary ammonium compounds have been shown to be stable in aqueous, alcohol and alcohol/aqueous solutions for extended periods, e.g. at least five years under standard laboratory conditions.
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Weight: 1.5-3 kg bw
Animals were maintained under standard laboratory conditions for a minimum of seven days, prior to the administration of the test substance
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Dose route: Topical occluded; abraded skin
- Duration of exposure:
- Post exposure period: 24 hours with test substance, 14 days after removal of dressing
- Doses:
- 0.5, 1.0, 2.0, 2.52, 3.96 g a.i./kg bw
- No. of animals per sex per dose:
- 5/group (mixed sex)
- Control animals:
- no
- Details on study design:
- Examinations made:
Clinical signs: Yes
Mortality: Yes
Bodyweight: Yes
Other examinations: A complete gross necropsy was performed on all animals - Statistics:
- The LD50 together with 95% confidince limits was determined, where possible, by the method of Litchfield and Wilcoxin (1949): Acute Toxicity, J. Pharm. Exp. Ther., 96-99.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 300 mg/kg bw
- Based on:
- act. ingr.
- 95% CL:
- ca. 1 460 - ca. 3 630
- Mortality:
- Refer the table 1
- Clinical signs:
- Depression was noted in 1 an 2 animals in the 2000 and 3960 mg a.i./kg dose groups, respectively.
- Body weight:
- Refer the table 2
- Gross pathology:
- Gross necropsy observations were recorded; however no consistent findings were noted.
Any other information on results incl. tables
Mortality: Table - 1
Dose levels (g/kg) |
Mortality (# Dead/# Dosed) |
% mortality |
0.5 |
0/5 |
0 |
1.0 |
1/5 |
20 |
2.0 |
3/5 |
60 |
2.52 |
2/5 |
40 |
3.96 |
2/8 |
40 |
Body weight: Table - 2
Dose levels (g/kg) |
Animal # |
Bodyweight (kg) |
|
Initial |
Final |
||
0.5 |
1 |
2.59 |
2.94 |
2 |
2.19 |
2.56 |
|
3 |
1.76 |
1.92 |
|
4 |
2.37 |
2.52 |
|
5 |
1.72 |
1.49 |
|
1.0 |
1 |
1.68 |
1.78 |
2 |
1.82 |
1.86 |
|
3 |
2.15 |
1.98 |
|
4 |
2.15 |
2.17 |
|
5 |
1.96 |
1.62 |
|
2.0 |
1 |
2.28 |
1.49 |
2 |
2.13 |
2.00 |
|
3 |
1.80 |
1.43 |
|
4 |
1.37 |
1.73 |
|
5 |
1.71 |
1.12 |
|
2.52 |
1 |
2.14 |
1.88 |
2 |
1.66 |
1.42 |
|
3 |
1.44 |
1.62 |
|
4 |
1.77 |
1.78 |
|
5 |
2.20 |
1.30 |
|
3.96 |
1 |
1.96 |
1.25 |
2 |
2.41 |
2.25 |
|
3 |
1.89 |
1.52 |
|
4 |
2.11 |
1.29 |
|
5 |
1.63 |
1.35 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Category 4 based on EU CLP criteria
- Conclusions:
- Under study conditions, the LD50 of the test substance was determined to be 2300 mg a.i./kg
- Executive summary:
A study was conducted to determine the acute dermal toxicity of the test substance, C12-18 ADEBAC (active: 50%), according to the method described by Hagan et al 1959 (Acute Toxicity; Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics, pp. 17-25, 1959) and similar to the OECD 402 guideline. A total of twenty-five rabbits were used to conduct the study. Each rabbit was given a single dose of the test substance at dose levels ranging from 500 to 2960 g a.i./kg bw. Applications were made to the skin, mildly shaved and abraded under 1”x1” gauze patches over 10% of the body surface. After dosing, the sites were covered with an impermeable plastic wrapping for 24 h. After removal of the dressing, the test sites were gently cleansed and the animals were observed for 14 d for toxic effects. Depression was noted in 1 an 2 animals in the 2000 and 3960 mg a.i./kg bw dose groups, respectively. Gross necropsy observations were recorded, however no consistent findings were noted. Under study conditions, LD50 for the test substance was determined to be 2300 mg a.i./kg bw with 95% confidence limits of 1460 to 3630 mg/kg bw. (Palanker 1976).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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