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EC number: 266-719-9 | CAS number: 67564-91-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to birds
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to birds: acute oral toxicity test (LD50-only)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08.11.1999- 20.01.2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Guideline:
- EPA OPP 71-1 (Avian Acute Oral Toxicity Test)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Fenpropimorph (Reg. No. 108 406); batch no. N 103; purity: 96.6%
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Details on preparation and analysis of diet:
- Concentration control of feed samples were performed using HPLC with
external calibration - Test organisms (species):
- Colinus virginianus
- Details on test organisms:
- TEST ORGANISM
- Common name: Bobwhite quail
- Source: Morris Hatchery Inc., Goulds (Maimi), Florida 33170-5399, USA
- Age at test initiation: approx. 6 months at study start;
before their first egg-Iaying; visually indistinguishable from wild birds
- Weight at test initiation (mean and range, SD):
- Sexes used: mixed - mala and female birds (determination due to coloration of plumage at that age)
- Disease free: yes; no medical treatment
- Kept according to standard practices: yes - Limit test:
- no
- Total exposure duration (if not single dose):
- 14 d
- Remarks:
- Birds treated once administering the test substance in a carrier (aequeous CMC dispersion) by gavage into the crop (5 males / 5 females per dose group). 14 days observation period.
- No. of animals per sex per dose and/or stage:
- 5 males / 5 females per dose group
- Control animals:
- yes, concurrent vehicle
- Nominal and measured doses / concentrations:
- 0 (carrier control), 500, 1000, 2000 mg a.s./kg b.w. (nominal);
The analytically detected concentrations were between 96.7% and 98.6% of the nominal concentrations. Hence results confirm the theoretical values. - Details on test conditions:
- ACCLIMATION
- Feeding: commercial quail diet: "Ssniff" experimental diet, special mixture for quail in meat form, Ssniff Spezialitäten GmbH, Soest, Germany;
Drinking water: minicipal water ad libitum throughout maintanance and study
- Health (any disease or mortality observed): Healthy, no medical treatment
- Fasting period before study: Birds fasted 15h - 20 h before administration of the test substance
FEED WITHHOLDING PERIOD BEFORE DOSING
- No. of hours: 15h - 20 h
PEN SIZE AND CONSTRUCTION MATERIALS
- Description: stainless steel wire mesh (0.59 x 0.45 x 0.26m)
- Floor covering: wire mesh floors, mesh size 10 x 15 mm
- Caging: group of 5 birds; male and female were separated
TEST CONDITIONS (range, mean, SD as applicable)
- Temperature: 21°C ± 2°C
- Relative humidity (%): 35% - 70%
- Photoperiod: 10:14 hours light : dark
RANGE FINDING STUDY: No - Key result
- Duration (if not single dose):
- 14 d
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Conc. / dose based on:
- act. ingr.
- Basis for effect:
- mortality
- Duration (if not single dose):
- 14 d
- Dose descriptor:
- NOEL
- Effect level:
- 1 000 mg/kg bw
- Conc. / dose based on:
- act. ingr.
- Basis for effect:
- mortality
- Further details on results:
- Analytical measurements: The concentration control analysis was performed for all dose levels. The analytically detected concentrations were between 96.7% and 98.6% of the nominal concentrations. Hence results confirm the theoretical values.
Biological results: No mortality occurred in any of the dose groups. 4 hours after the application transiently soft faeces were observed in all dose groups, but not in the control group. This effect was, however, not considered to be adverse. The feed uptake in the first week after application was reduced in the group dosed with 2000 mg a.s./kg b.w.. In the second week of the study no test substance-related impairment of feed uptake in comparison to the control was observed in any of the dose groups. There was no statistically significant test substance related reduction of the body weights in any of the dose groups at study termination. Body weight was however reduced in the females of dose group 2000 mg a.s./kg b.w. - Reported statistics and error estimates:
- One-way analysis (ANOVA) followed by Dunnett's test
- Conclusions:
- In the acute toxicity test (single-dose oral application) of Fenpropimorph to the bobwhite quail the LDso (14 d) was greater than 2000 mg a.s./kg b.w., the highest concentration tested.
The NOEL was found to be 1000 mg as. /kg b.w.
Reference
Table 1: Acute toxicity of Fenpropimorph to the bobwhite quail (Colinus virginianus) | |
Mortality | Dose [mg a.s./kg b.w.] |
|
|
Highest dose causing no compound-related mortality | 2000 |
LD50 (14 d) | > 2000 |
NOEL (14 d) | 1000 |
Description of key information
Fenpropimorph was tested on mallard ducks (Anas platyrhynchos) and bobwhite quails (Colinus virginianus). The studies performed cover a broad range of biological endpoints, such as mortality, signs of toxicity, feed consumption, body weight, post-mortem examinations and various reproduction parameters. LD50 was determined to be > 2000 mg a.s./kg body weight (single dose application) and LC50 > 5000 mg a.s./kg diet (dietary feeding test). Two long-term avian reproduction studies were performed and resulted in NOEC-values of 45 mg a.s./kg feed and 333 mg a.s./kg feed, the highest concentrations tested.
Key value for chemical safety assessment
- Short-term EC50 or LC50 for birds:
- 5 000 mg/kg food
- Long-term EC10, LC10 or NOEC for birds:
- 45 mg/kg food
Additional information
Five studies on the acute and chronic toxicity of fenpropimorph to aquatic invertebrates are available. All studies were conducted according to GLP and different international guidelines. The test species was the bobwhite quail (Colinus virginianus) and the mallard duck (Anas platyrhynchos).
The studies performed cover a broad range of biological endpoints, such as mortality, signs of toxicity, feed consumption, body weight, post-mortem examinations and various reproduction parameters. The results of the studies are summarised below. The feed concentrations were transformed to daily doses (mg/kg body weight/day) by the notifier based on the study data.
Table 1: Summary of effects of fenpropimorph on birds
Test species | Test system | Results |
Colinus virginianus | acute oral toxicity | LD50 > 2000 mg a.s./kg body weight; NOEL = 1000 mg a.s./kg body weight |
Anas platyrhynchos | short-term dietary toxicity | LC50 > 5000 mg a.s./kg feed; NOEC = 1250 mg a.s./kg feed |
Colinus virginianus | short-term dietary toxicity | LC50 > 5000 mg a.s./kg feed; NOEC = 5000 mg a.s./kg feed |
Colinus virginianus | Sub-chronic toxicity and reproduction | NOEC = 45 mg a.s./kg feed; NOEC = 333 mg a.s./kg feed |
BASF DocumentID | Test substance | Guideline GLP | Test species | Test System | Endpoints | Results |
2000/1000184 | fenpropimorph | EPA 71-1 Yes | Colinus virginianus | acute oral toxicity, 14d (nom) | Mortality, clinical signs, feed consumption, body weight | LD50 > 2000 mg a.s./kg body weight |
1988/0635 | fenpropimorph |
EPA 71-2 Yes | Anas platyrhynchos | short-term dietary toxicity, 8d (nom) | Mortality, signs of toxicity, feed consumption, body weight | LC50 > 5000 mg a.s./kg feed NOEC = 1250 mg a.s./kg feed |
1988/0636 | fenpropimorph | EPA 71-2 Yes | Colinus virginianus | short-term dietary toxicity, 8d (nom) | Mortality, signs of toxicity, feed consumption, body weight | LC50 > 5000 mg a.s./kg feed NOEC = 5000 mg a.s./kg feed |
1983/10086 | fenpropimorph | EPA 71-4 Yes | Colinus virginianus | Sub-chronic toxicity and reproduction, 24w (nom) | Mortality, signs of toxicity, feed consumption, body weight, macroscopic post mortem examination, nr of eggs laid, nr of broken/cracked eggs, egg weights/shell thickness, nr of infertile eggs, embryonic deaths, hatching, chick health and mortality, nr of 14-day survivors, body weights of offspring | NOEC = 45 mg a.s./kg feed |
2002/1005241 | fenpropimorph | EPA 71-4 Yes | Colinus virginianus | Sub-chronic toxicity and reproduction, 21w (nom) | Mortality, body weights of adult birds, reproduction parameter: number of eggs laid, fertility, embryo viability, hatchability, offspring survival, eggshell strength and thickness | NOEC = 333 mg a.s./kg feed |
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