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Diss Factsheets
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EC number: 231-272-0 | CAS number: 7473-98-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From Jun. 1978 to Mar. 6, 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- - more stringent protocol with 24h occlusive application, data for single animals not given
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-hydroxy-2-methylpropiophenone
- EC Number:
- 231-272-0
- EC Name:
- 2-hydroxy-2-methylpropiophenone
- Cas Number:
- 7473-98-5
- Molecular formula:
- C10H12O2
- IUPAC Name:
- 2-hydroxy-2-methyl-1-phenylpropan-1-one
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Chbb: HM -SPF
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: animals purchased
- Age at study initiation: Not reported
- Weight at study initiation: 2.14 to 2.75 kg (mean weight of 2.35 kg)
- Fasting period before study: Not reported
- Housing: standard cages (manufactured by Becker) on metal floor grids.
- Diet (e.g. ad libitum): Brand-Purina mixed feed manufactured by Kraftfutterwerke GmbH, Wisebaden-Schierstein branch ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: Not reported
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 27 ± 7
- Humidity (%): 52 ± 20
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): Not reported
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: abraded / intact
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
CONTROL:
0.5 mL of water was appliaed in a similar fashion to the right half of the animals' backs - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 7 days
- Number of animals:
- 4 females tested with intact skin and 4 females tested with scarified skin
- Details on study design:
- TEST SITE
- Area of exposure: back
- % coverage: 4 cm2
REMOVAL OF TEST SUBSTANCE
- Washing (if done): After patches were removed, any remaining substance was washed off with water.
- Time after start of exposure:24 hours
SCORING SYSTEM: Local changes were assessed according to the DRAIZE (1959).
Degree of irritation:
0 = without irritation
1 = questionable
2 = slight
3 = pronounced
4 = severe
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- intact skin
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0.25
- Max. score:
- 1
- Reversibility:
- fully reversible within: 3 days
- Irritation parameter:
- erythema score
- Remarks:
- intact skin
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0.25
- Max. score:
- 1
- Reversibility:
- fully reversible within: 3 days
- Irritation parameter:
- erythema score
- Remarks:
- intact skin
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Remarks:
- intact skin
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Remarks:
- intact skin
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Remarks:
- intact skin
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Remarks:
- intact skin
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Remarks:
- scarified skin
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Remarks:
- scarified skin
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0.25
- Max. score:
- 1
- Reversibility:
- fully reversible within: 3 days
- Irritation parameter:
- erythema score
- Remarks:
- scarified skin
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- The single application of 0.5 ml of the test item to the shorn skin on the backs of each of the rabbits did not show signs of irritation after the 24-hour exposure period.
- Other effects:
- All of the rabbits were clinically normal. The body weight did not differ from that of rabbits of the same age that were not treated. All of the animals survived the 7-day observation period.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test item was found to be not irritant to the skin.
- Executive summary:
In this (OECD 404) study conducted to generally accepted scientific standards, the test material (EC 231 -272 -0) was induced mean erythema scores of 0.25 in 1 of the 4 test animals (rabbit, intact skin) across the 24 and 48 hour observation periods. In addition a mean erythema score of 0.25 was observed for one test animal with scarified skin at the 48 hour observation period. All applications occured under occlusive conditions and were fully reversible within 3 days. The result of the test is not sufficient to meet the criteria for classification as a skin irritant under the criteria of the EU Classification, Labelling, and Packaging (CLP) regulation (1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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