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Diss Factsheets
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EC number: 203-905-0 | CAS number: 111-76-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
A number of studies have been carried out using multiple species of fish, both fresh and salt water. A guideline study in freshwater fish that is available as both the original study and a publication along with a second study in a saltwater species are sufficiently well reported to judge them as reliable and are used to derive the key parameters. All the other available experimental studies, are highly consistent with the key studies and provide evidence to support a narcotic mode of action and an indication that 2 -butoxyethanol is essentially non-toxic to fish over the acute timeframe. The acute LC50 value is 1464mg/l in freshwater fish. In a 21 day study in fish (Brachydanio rerio) that was designed to examine the potential for endocrine disrupting effects and which was based around the OECD guideline, there was no evidence of any adverse effects, including on endocrine markers, up to and including the maximum tested dose of 100mg/l.
A number of studies have been carried out using multiple species of invertebrates, both fresh and salt water. These indicate that 2 -butoxyethanol is of low toxicity to invertebrates. Some of these studies were not performed for the normally required 48hrs (only 24hr studies) however one study was for the requisite period and to a modern protocol and in the preferred daphnia magna species. Since this produced the lowest value (except for one study for which full details are not available and which showed some inconsistency in the results) it is selected as a key study. In addition, there is reliable data in a seawater species. (albeit only a 24hr study). There are also 2 studies available using hydra species. Since one of these gave a lower IC50 value than daphnia, it is used to derive the acute PNEC for this species. Two chronic studies are available in invertebrates. Both gave reasonably consistent results. The 21 day study in daphnia magna is considered the most reliable as this is a full guideline study with no significant shortcomings.
A small number of algal toxicity studies are available. Two of them are considered key studies suitable to derive the key parameter for this end point.
A number of studies have been carried out to assess the toxicity of 2 -butoxyethanol to micro-organism using multiple species of protozoa and bacteria in fresh water. The studies that are reliable indicate that the substance may be slightly toxic to micro-organisms. The weight of evidence suggested that the substance is generally of low toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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