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EC number: 629-716-7 | CAS number: 1211950-04-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 Mar - 23 Mar 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: pre-GLP; Includes GLP-like QA statement.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- N,N,N',N',N''-Pentamethyl-N-C16-18 (even numbered) C18 unsat.-alkyl-1,3-propanediammonium chloride
- EC Number:
- 629-716-7
- Cas Number:
- 1211950-04-7
- Molecular formula:
- No molecular formula
- IUPAC Name:
- N,N,N',N',N''-Pentamethyl-N-C16-18 (even numbered) C18 unsat.-alkyl-1,3-propanediammonium chloride
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- water
- Reference substance name:
- Propan-2-ol
- EC Number:
- 200-661-7
- EC Name:
- Propan-2-ol
- Cas Number:
- 67-63-0
- Molecular formula:
- C3H8O
- IUPAC Name:
- propan-2-ol
- Test material form:
- liquid
- Details on test material:
- - Chemical name : N,N,N',N',N''-Pentamethyl-N-C16-18 (even numbered) C18 unsat.-alkyl-1,3-propanediammonium chloride
- EC number : 629-716-7
“Based on the qualitative and quantitative information on the composition, the sample used are representative of the boundary composition shared and agree by each registrant.”
The concentrations cited in this memo refer to the as-received sample of Duoquad T-50.
Constituent 1
Constituent 2
Constituent 3
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Three New Zealand White strain rabbits in the weight range 2.5 to 3.1 kg, prior to treatment on Day 1 and approximately 11 to 14 weeks of age were
obtained from Froxfield Rabbits, Petersfield, Hampshire. The rabbits selected for the study were all acclimated to the laboratory environment.
The rabbits were individually housed in metal cages with perforated floors in Building R 14 Room 3. They had free access to tap water and SDS
Standard Rabbit Diet. Animal room temperature was maintained at approximately 19°C and relative humidity at 30-70%. Air exchange was
maintained at approximately 19 air changes per hour and lighting was controlled to give 12 hours of artificial light (0700-1900 hours) in each 24
hour period. All animals were observed daily for signs of ill health or toxic signs.
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.1 ml
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- The eyes of each animal were examined prior to instillation of the test substance to ensure that there was no pre-existing corneal damage or
conjunctival inflammation. A 0.1 ml aliquot of Redicote EN 611 was placed into the lower everted. lid of one eye of each animal. The eyelids
were then gently held together for one second before releasing. The contralateral eye remained untreated and served as a control.
Examination of the eyes was made after 1 hour and 1, 2, 3, 4 and 7 days after instillation. Observation of the eyes was aided by the use of a hand held
torch.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2.67
- Max. score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not specified
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 1
- Reversibility:
- not specified
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not specified
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 1
- Reversibility:
- not specified
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: Vascularization of cornea on day 7
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 2
- Reversibility:
- not specified
- Irritant / corrosive response data:
- All three animals gave a "positive" response. Corneal opacification developed in all three animals and was still present seven days after instillation,
when vascularisation of the cornea was also seen in one animal. Iridial inflammation was observed in all three animals. A diffuse, crimson colouration of the conjuntivae accompanied by swelling with partial eversion of the eyelids or with the eyelids about half-closed was seen in all three animals.
A copious discharge was observed in all three animals. All three animals were killed on humane grounds, seven days after instillation, due to the
severity of the ocular reactions.
Any other information on results incl. tables
Summary of ocular lesions
Anim. No. | Effect | Hours | Days after application | Mean score cornea Days 1/2/3 | Mean score iritis Days 1/2/3
| Mean score redness Days 1/2/3 | Mean score chemosis Days 1/2/3 | ||||
1 | 1 | 2 | 3 | 4 | 7
| ||||||
1 | Cornea Iris Redness Chemosis | D 0 2 2 | 1 0 2 1 | 1 1 2 1 | 2 1 2 1 | 2 1 2 1
| 2 0K 1 1
| 1.33 | 0.67 | 2 | 1 |
2 | Cornea Iris Redness Chemosis | D 0 1 2 | 1 1 1 3
| 1 1 2 2
| 2 1 2 3
| 2 1 2 3
| 1 1K 2 2
| 1.33 | 1 | 1.67 | 2.67 |
3 | Cornea Iris Redness Chemosis | D 0 1 2
| 1 0 1 1
| 2 1 2 2
| 2 1 2 2
| 2 1 2 2
| 3V 1K 2 2 | 1.67 | 0.67 | 2 | 2 |
D Dulling of cornea
V Vascularization of cornea
K Killed
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Instillation of Redicote EN 611 into the rabbit eye elicited a positive response in all of the three treated animals according to OECD test criteria.
Severe ocular reactions were observed including vascularization of the cornea. Based on the severity of the reactions, the test article should be
classified as corrosive under GHS. - Executive summary:
The study was conducted to asseses the irritation potential of Redicote EN 611 when instilled into the eyes of rabbits in accordance with OECD 405. 0.1 ml was instilled into one eye of three rabbits. Eye were evaluated 1 hour after instillation and again 1, 2, 3, 4 and 7 days later.
Instillation of Redicote EN 611 into the rabbit eye elicited a positive response in all of the three treated animals according to OECD test criteria. Severe ocular reactions were observed including vascularization of the cornea. Based on the severity of the reactions, the test article should be classified as corrosive under GHS.
Label requirements under GHS: Symbol "Corrosion"; Signal word "Danger"; Hazard statement "Causes serious eye damage"
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