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Diss Factsheets
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EC number: 205-622-8 | CAS number: 144-29-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Piperazine (CAS No 110-85-0) is the parent molecule from which piperazine citrate has been prepared.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- European Union Risk Assessment Report: Piperazine
- Author:
- European Chemicals Bureau
- Year:
- 2 005
- Bibliographic source:
- European Union Risk Assessment Report – PIPERAZINE, 3rd Priority List Volume: 56;Final Report, 2005; EUR 21642 EN
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Skin irritation test was conducted in white rabbits for test chemical Piperazine according to OECD Test Guideline 404.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Piperazine
- EC Number:
- 203-808-3
- EC Name:
- Piperazine
- Cas Number:
- 110-85-0
- Molecular formula:
- C4H10N2
- IUPAC Name:
- Piperazine
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report): Piperazine- Molecular formula : C4H10N2- Molecular weight : 86.137 g/mole- Substance type:Organic- Physical state: Solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Weisser Wiener
- Details on test animals or test system and environmental conditions:
- Sex: Male and female- Housing: kept individually
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 500 mg (50% aqueous solution )
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- after 30-60 minutes, 24, 48 and 72 hours
- Number of animals:
- 3 (2 males and 1 female)
- Details on study design:
- - Area of exposure: 6.25 cm2- Type of wrap if used: Gauze patchThe fur was removed by close clipping at least 15 hours pre dosing.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48 and 72 hours
- Remarks on result:
- other: Severe erythema and necrosis was observed in all animals
- Irritant / corrosive response data:
- Severe erythema and necrosis was observed in all animals.Strongly irritating to the skin
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The test chemical Piperazine (CAS No: 110-85-0) was observed to be irritating on skin of rabbits.
- Executive summary:
Skin irritation study was carried out in 3 (2 males and 1 female)Weisser Wienerwhite rabbits for test chemical Piperazine (CAS No: 110-85-0) according to OECD Guideline 404 to assess its irritation potential.
The rabbits were kept individually and the fur was removed by close clipping at least 15 hours pre dosing. About 500mg of piperazine in a 50% aqueous solution (assumingly piperazine base) was applied to a 6.25 cm2 gauze patch and applied to the skin and covered with a semi-occlusive dressing. After exposure for 4 hours, the test substance was removed, and the skin reaction evaluated after 30-60 minutes, 24, 48 and 72 hours, respectively. Observations at 48 and 72 hours revealedSevere erythema and necrosis in all animals. Hence the test chemical Piperazine (CAS No: 110-85-0) was considered as a strong skin irritant.
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