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EC number: 266-719-9 | CAS number: 67564-91-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sediment toxicity
Administrative data
- Endpoint:
- sediment toxicity: long-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08.03.- 02.09.1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: method for a sediment toxicity test developed by a BBA/IVA working group
- Version / remarks:
- Barrett et al., 1994
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- cis-4-[3-(p-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine
- EC Number:
- 266-719-9
- EC Name:
- cis-4-[3-(p-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine
- Cas Number:
- 67564-91-4
- Molecular formula:
- C20H33NO
- IUPAC Name:
- (2R,6S)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test organisms
- Test organisms (species):
- Chironomus riparius
- Details on test organisms:
- TEST ORGANISM
- Common name: harlequin fly
- Source: originally obtained from a laboratory culture of the University of Sheffield (UK), cultures maintained in-house
Study design
- Study type:
- laboratory study
- Test type:
- static
- Water media type:
- freshwater
- Type of sediment:
- artificial sediment
- Limit test:
- no
Test conditions
- Hardness:
- 2.51 mmol/L
- Test temperature:
- 19- 20 °C
- pH:
- 8.2
- Dissolved oxygen:
- 9.1 mg/L
- Conductivity:
- 628 µS/cm
- Nominal and measured concentrations:
- 0 (control), 0.005, 0.025, 0.125 mg a.s./L (nominal)
- Details on test conditions:
- TEST SYSTEM
- Test container (material, size): 2 1glass beakers (tall form, 11.7 cm diameter)
- Sediment volume: 2 cm high layer of the articial sediment (corresponding to 237 g sediment).
- Weight of wet sediment with and without pore water:
- Overlying water volume: 18 cm height of reconstituted water
- Depth of sediment and overlying water: 2 cm sediment plus 18 cm water column
- Aeration: yes
- Aeration frequency and intensity: gently aerated via Pasteurpipettes
EXPOSURE REGIME
- No. of organisms per container (treatment): 25
- No. of replicates per treatment group: 3
- No. of replicates per control / vehicle control: 3
- Feeding regime: regularly fed with fish food extract
OVERLYING WATER CHARACTERISTCS
- Type of water: Elendt medium acc. to OECD 219
CHARACTERIZATION OF ARTIFICIAL SEDIMENT
- Composition (if artificial substrate): 1 % CaCO3 (Merck 2069),
10% sphagnum moss peat (weakly-middle decomposed, "Compo Naturgarten Gärtnertorf“, DIN 11540—175),
20% Kaoline (kaolinite content > 30 %),
69%, quartz sand (0421/ISSO-trocken, Fa. Gebr. Willersinn
Particle size: 3 80 % 0.063 - 0.2 mm)
- Method of preparation (if artificial substrate): dry components are blended thoroughly under the addition of some water
- pH dry matter and/or whole sediment: 6.5
- Total organic carbon (%): 5%
OTHER TEST CONDITIONS
- Photoperiod (day:night-rhythm): 16:8 hours
- Light intensity: ca 400-550 lux (white uorescent tube)
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Daily assessments of behaviour, mortality and emergence. The number, time and sex of emerged adults is recorded.
Results and discussion
Effect concentrations
- Key result
- Duration:
- 20 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.125 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- development rate
- Details on results:
- Analytical measurements: Mean measured test concentrations of Fenpropimorph at test start were in the range of 57.3% - 78.3% of nominal. The lower recovery rate at test start was due to the low water solubility and the rapid dissipation to sediment of the test substance. At the end of the test - after 20 days - Fenpropimorph could not be detected in the overlaying water due to adsorption.
Biological results: Fenpropimorph caused no effects on the chironomids up to the highest concentration tested, 0.125 mg a.s./L. There was neither a significant reduction in the numbers of emerged adults nor in the development of the larvae.
The results are summarized below in table 1.
Any other information on results incl. tables
Table 1: Effect of Fenpropimorph on Chironomus riparius | ||||
Concentration | Control | 0.005 | 0.025 | 0.125 |
Concentration | Control | 0.0035 | 0.015 | 0.082 |
|
|
|
|
|
No. of emerged midges | 73 | 71 | 73 | 72 |
Emergence of inserted larvae [%] | 97.3 | 94.7 | 97.3 | 96.0 |
No. of emerged midges | 35/38 | 37/34 | 40/33 | 37/35 |
Mean emergence time [d] | 15.3 | 15.6 | 15.5 | 15.4 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- For fenpropimorph the NOEC was determined to be 0.125 mg a.s./L (nominal).
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