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EC number: 422-630-9 | CAS number: 22208-25-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key study: EU Method B.1 (GLP study). The oral LD50 in rats was determined to be higher than 2000 mg/kg bw.
Key study: EU Method B.3 (GLP study). The dermal LD50 in rats was determined to be higher than 2000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- Crl:(WI) BR
- Sex:
- male/female
- Route of administration:
- oral: unspecified
- Vehicle:
- other: No vehicle was used. The test substance was dosed undiluted.
- Doses:
- 2000 mg/kg bw
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- not specified
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- salivation
- Body weight:
- other body weight observations
- Remarks:
- The body weight gain of the animals over the study period was considered to be similar to that expected of normal animals of the same age and strain.
- Gross pathology:
- Macroscopic post mortem examination of the animals at termination did not reveal any abnormalities.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The oral LD50 in rats was higher 2000 mg/kg bw.
- Executive summary:
The study was conducted according to EU Method B.1 and OECD 401 (GLP study). Albino wistar male and female rats were exposed orally to 2000 mg/kg bw test substance (limit test). Not significant clinical signs neither organ effects were observed. Thus, the oral LD50 was determined to be higher than 2000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 2 000 mg/kg bw
- Quality of whole database:
- The study is a GLP compliant and has a Klimisch score 1.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- GLP compliance:
- yes
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- Crl:(WI) BR
- Sex:
- male/female
- Type of coverage:
- semiocclusive
- Vehicle:
- other: No vehicle was used. The test substance was dosed undiluted.
- Duration of exposure:
- 24 h
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- not specified
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other:
- Body weight:
- other body weight observations
- Remarks:
- The animals showed expected body weight gain during the study
- Gross pathology:
- No abnormalities were found at macroscopic post mortem examination
- Other findings:
- Signs of toxicity (local):
Erythema, scales and scabs in the treated skin-area and red staining in the neck were seen among several animals during the observation period.
The animals had recovered from the symptoms between days 5 and 8, except for red staining in the neck of one female which persisted until termination of the study. - Interpretation of results:
- GHS criteria not met
- Conclusions:
- The dermal LD50 in rats was determined to be higher than 2000 mg/kg bw.
- Executive summary:
The study was conducted according to EU Method B.3 (GLP study). Wistar Crl:(WI) BR male and female rats were treated with the substance at 2000 mg/kg bw (limit test). Due to the absence of mortality, relevant clinical signs and abnormalities in the organs, the dermal LD50 was determined to be higher than 2000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 2 000 mg/kg bw
- Quality of whole database:
- The study is GLP compliant nad has a Klimisch score 1.
Additional information
Justification for classification or non-classification
Based on the available data (LD50 > 2000 mg/kg bw), the substance does not need to be classified for acute toxicity according to the CLP Regulation (EC) no. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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