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Diss Factsheets
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EC number: 204-018-1 | CAS number: 112-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
There is no data available for this substance. However, key, weight-of-evidence and supporting data is available for structural analogues. The data is read across to this substance based on analogue read across and a discussion and report on the read across strategy is provided as an attachment in IUCLID Section 13.
The substances are poorly soluble and made of constituents with various water solubility. As a consequence, the exposures were performed with Water Accommodated Fractions (WAFs). Therefore, the results are based on nominal loadings.
The toxicity level was never reached in any fish, aquatic invertebrate, algal or microorganism acute study despite the high loading level tested. Therefore, this substance is considered to display no acute aquatic toxicity based on an analogue read across approach.
For the chronic effects, very long term exposure to 1% pristane, 1% dodecylcyclohexane or 1% n-alkanes in diet reduces fish appetite, fish growth, lipid digestibility and canthaxanthin fixation in rainbow trout. The effects are reversible. The 21-day No Observed Effect Loading Rates (NOELRs) based on adult immobilization and reduction in reproduction of aquatic invertebrates was 5 mg/L.
Additional information
Key and weight-of-evidence information is summarised below:
Short-term toxicity to fish
Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics presented a 96-h LL50 (mortality) for juveniles of the marine fish Scophthalmus maximus of > 1028 mg/L (based on nominal loading rate).
Hydrocarbons, C12-C16, isoalkanes, cyclics, <2% aromatics presented a 96-h LL50 value for Oncorhynchus mykiss of >87,556 mg/L (based on water accomodated fractions).
The toxicity level was never reached in any study despite the high loading level tested. Therefore, this substance is considered to display no acute toxicity to fish based on an analogue read across approach.
Long-term toxicity to fish
1% pristane, 1%dodecylcyclohexane or 1% n-alkanes long-term exposures in fish diet reduced fish appetite, fish growth, lipid digestibility and canthaxanthin fixation in rainbow trout. The effects were reversible.No NOELR or NOEC value has been determined for long-term toxicity to fish.
Short-term toxicity to aquatic invertebrates
Hydrocarbons, C14-C16, n-alkanes, isoalkanes, <2% aromatics presented a 48-h EL50 for Daphnia magna of >100 mg/L (WAF) based on mobility.
Hydrocarbons, C15-C19, n-alkanes, isoalkanes, <2% aromatics presented a 48-h EL50 for Daphnia magna of >100 mg/L (WAF) based on mobility.
Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics presented a 48-h LL50 for Acartia tonsa of > 3193 mg/L (based upon nominal loading rate).
Hydrocarbons, C11-C14, n-alkanes, isoalkanes, cyclics, <2% aromatics presented a 48-h LL50 for Daphnia magna of >1000 mg/L.
Hydrocarbons, C11-C14, n-alkanes, isoalkanes, cyclics, <2% aromatics presented a 96-h LL50 for Chaetogammarus marinus of >10,000 mg/L.
No LC50 or LL50 could be derived from the acute toxicity studies for aquatic invertebrates. The toxicity level was never reached in any study despite the high loading level tested. Therefore, this substance is considered to display no acute toxicity to aquatic invertebrates based on an analogue read across approach.
Long-term toxicity to aquatic invertebrates
Hydrocarbons, C13-C16, isoalkanes, cyclics, <2% aromatics presented 21-d No Observed Effect Loading Rates (NOELRs) for Daphnia magna of 5 mg/L, based on adult immobilization and reduction in reproduction.
Hydrocarbons, C12-C15, n-alkanes,<2% aromatics presented 6-d NOELRs for Ceriodaphnia dubia of >100% WAF, based on mortality and reproduction.
Toxicity to algae and cyanobacteria
Hydrocarbons, C14-C16, n-alkanes, isoalkanes, <2% aromatics presented a 72-h EL50 (growth rate) for Pseudokirchneriella subcapitata of >100 mg/L (WAF) and a 72-h NOELR (growth rate) for Pseudokirchneriella subcapitata of 100 mg/L.
Hydrocarbons, C15-C19, n-alkanes, isoalkanes, <2% aromatics presented a 72-h EL50 (growth rate) for Pseudokirchneriella subcapitata of >100 mg/L (WAF) and a 72-h NOELR (growth rate) for Pseudokirchneriella subcapitata of 100 mg/L.
Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics presented a 72-h EL50 (growth rate) for Skeletonema costatum of >3200 mg/L (based upon loading rates) and a 72-h NOELR (growth rate) for Skeletonema costatum of 993 mg/L.
Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics presented a 72-h EL50 (growth rate) for Skeletonema costatum of >10000 mg/L.
Hydrocarbons, C11-C14, n-alkanes, isoalkanes, cyclics, <2% aromatics presented a 72-h EL50 (growth rate) for Pseudokirchnerella subcapitata of >1000 mg/L and a 72-h NOELR (growth rate) for Pseudokirchnerella subcapitata of 1000 mg/L.
The toxicity level was never reached in any study despite the high loading level tested. Therefore, this substance is considered to display no acute toxicity to algae based on an analogue read across approach.
Toxicity to microorganisms
Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics presented a 3h-EC50 (respiration inhibition) for activated sludge of >100 mg/L.
This substance is considered to display no acute toxicity to aquatic microorganisms based on an analogue read across approach.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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