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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: simillar to guideline

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Principles of method if other than guideline:
10 male Wistar rats/ group received single doses of the test item by gavage and were observed for clinical signs and mortality for 14 days
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Aminoguanidinium hydrogen carbonate
EC Number:
219-956-7
EC Name:
Aminoguanidinium hydrogen carbonate
Cas Number:
2582-30-1
Molecular formula:
CH6N4.CH2O3
IUPAC Name:
carbamimidoyldiazanium hydrogen carbonate
Test material form:
other: solid
Details on test material:
content: ca. 99 %

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 180-200 g
- Housing: 5 per cage

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
10 male Wistar rats/ group received single doses of aminoguanidinium hydrogen carbonate by gavage and were observed for clinical signs and mortality for 14 days.
Doses:
3100, 5000 mg/kg bw
No. of animals per sex per dose:
10 males/group
Control animals:
no
Details on study design:
10 male Wistar rats/ group received single doses of aminoguanidinium hydrogen carbonate by gavage and were observed for clinical signs and mortality for 14 days.
Statistics:
no data

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Remarks on result:
other: In the 5000 mg group 4/10 animals died: sedation and poor general condition
Mortality:
No animal died in the 3100 mg/kg bw group.
4/10 animals died within 2 to 6 days in the 5000 mg/kg bw group.
Clinical signs:
other: 3100 mg/kg bw animals tolerated treatment without impairment 5000 mg/kg bw 10 /10: sedation, poor general condition
Gross pathology:
no details given

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information
Executive summary:

Groups of 10 male Wistar rats received single oral doses (3100 or 5000 mg/kg bw) of aminoguanidinium hydrogen carbonate dissolved in water and were observed for 14 days. Rats dosed with 3100 mg/kg bw tolerated the treatment without clinical signs or mortality. All 10 rats dosed with 5000 mg/kg bw showed sedation and poor general condition within 2 to 6 days after application of aminoguanidinium hydrogen carbonate, 4/10 died. Thus the LD50(oral) is >5000 mg/kg bw.