Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 265-176-5 | CAS number: 64742-71-8 A complex combination of hydrocarbons obtained from a catalytic dewaxing process. It consists predominantly of hydrocarbons having carbon numbers predominantly in the range of C15 through C30 and produces a finished oil with a viscosity of less than 100 SUS at 100°F (19cSt at 40°C).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1980-10-21 to 1980-10-28
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study is classified 'reliable without restriction' because it was conducted according to OECD guideline 405.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Observation for ocular irritation 1 hour post-exposure was not conducted as recommended by OECD Guideline 405.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 64742-56-9
- Cas Number:
- 64742-56-9
- IUPAC Name:
- 64742-56-9
- Reference substance name:
- Solvent dewaxed light paraffinic oil, sufficiently refined, IP 346 < 3%
- IUPAC Name:
- Solvent dewaxed light paraffinic oil, sufficiently refined, IP 346 < 3%
- Test material form:
- other: Oily liquid
- Details on test material:
- - Name of test material (as cited in study report): API 78-9 Solvent dewaxed light paraffinic oil
- CAS number: 64742-56-9
- API Identification number: API 78-9
Molecular weight (if other than submission substance): 322
- Substance type: Other Lubricant Base Oil (Sufficiently Refined, IP 346 < 3%)
- Physical state: Liquid
- Analytical purity: Not reported
- Stability under test conditions: Not reported
- Storage condition of test material: Stable at room temperature
- Other:
Specific gravity 60/60: 0.8490
API gravity: 35.2
Viscosity CS: 11.5 @ 100°F
Viscosity CS: 2.81 @ 210°F
Viscosity SUS: 64.2 @ 100°F
Viscosity SUS: 35.6 @ 210°F
Viscosity Index: 97
Viscosity-gravity constant: 0.807
Pour Point: -3°F
Aniline Point: 200.5 °F
Ramsbottom Carbon:0.03%
Density 20C: 0.8453
Refractive Index ND20:1.4675
UV Absorptivity, 260 nm: 0.500
UV Absorptivity, 290 nm: 0.261
UV Absorptivity, 343 nm: 0.002
Distillation range (°F) 597-751 (5 and 95%)
Initial Boiling Point (°F): 536
Final Boiling Point (°F): 782
- Composition of test material:
ASTMD-2007, Wt. %:
Asphaltenes: 0.0
Saturates: 88.7
Aromatics 11.3
Polar compounds: 0.0
Carbon Distribution (ndm)
% Aromatic carbons: 3
% Naphthenic carbons: 30
% Paraffinic carbons: 67
Sulfur, ppm: 490
Basic Nitrogen, ppm: 20
Total Nitrogen, ppm: 237
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Elkhorn Rabbitry (Watsonville, California)
- Age at study initiation: Not reported
- Weight at study initiation: 3.0 - 5.0 Kg
- Fasting period before study: Not reported
- Housing: Individual cage
- Diet (e.g. ad libitum): Purina Rabbit Chow® ad libitum
- Water (e.g. ad libitum): Fresh water ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported
- Humidity (%): Not reported
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): Not reported
IN-LIFE DATES: From: 1980-10-02 To: 1980-10-28
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Left eye of test animals served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL - Duration of treatment / exposure:
- Unwashed - single application with subsequent observation for 72 hours
Washed - single application folllowed by washing with water 30 seconds later and subsequent observation for 72 hours. - Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 9 (5 males, 4 females)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): Yes (water)
- Time after start of exposure: 30 seconds post exposure to TS
SCORING SYSTEM: Draize scoring method
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 80
- Remarks on result:
- other: unrinsed eye
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 10
- Remarks on result:
- other: unrinsed eye
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 12
- Remarks on result:
- other: unrinsed eye
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.11
- Max. score:
- 8
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: unrinsed eye
- Irritant / corrosive response data:
- See (Table 1) "Remarks on results including tables and figures"
Any other information on results incl. tables
Table 1. Mean Eye Irritation Scores for Male and Female Rabbits |
|||
|
24 hours |
48 hours |
72 hours |
Washed eyes |
0 |
0 |
0 |
Unwashed eyes |
0 |
0.33 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Rabbits with washed eyes exhibited no irritation through the 72-hour observation period. One male rabbit in the unwashed group exhibited conjunctival chemosis at the 48-hour observation period. The remaining rabbits showed no signs of irritation through the study period.
- Executive summary:
In a primary eye irritation study, 6 New Zealand White rabbits (3 male, 3 female) had 0.1 mL of dewaxed light paraffinic oil instilled into the conjunctival sac of their right eye. The left eyes of these rabbits served as treatment controls. Additionally, 3 rabbits (2 male, 1 female) were administered the test material in the right eye and the eyes were rinsed with warm water 30 seconds following exposure.
Ocular lesions were observed for at 24, 48, and 72 hours post-exposure and fluorescein dye evaluations employed for each reading. Grading and scoring of ocular irritation was performed according the method of Draize.
Rabbits with washed eyes exhibited no irritation through the 72-hour observation period. A single male rabbit in the unwashed group exhibited conjunctival chemosis at the 48-hour observation period. The remaining rabbits showed no signs of irritation through the study period.
Solvent dewaxed light paraffinic oil is not considered to be an ocular irritant.
This study is classified 'reliable without restriction' because it was conducted according to OECD guideline 405.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)