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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 203-571-6 | CAS number: 108-31-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1988
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Only secondary literature, no details available.
- Qualifier:
- according to guideline
- Guideline:
- other: Prolonged toxicity test according to a proposal of the German Federal Environmental Agency, Berlin (February 1984)
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Test type:
- not specified
- Water media type:
- freshwater
- Total exposure duration:
- 21 d
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 77 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- reproduction
- Validity criteria fulfilled:
- not specified
- Conclusions:
- NOEC (Daphnia magna, 21 d) = 10 mg/L (reproduction rate)
EC50 (Daphnia magna, 21 d) = 77 mg/L (reproduction rate) - Executive summary:
The 21-day chronic toxicity of maleic anhydride to Daphnia magna was studied. The 21-day EC50 based on reproduction was 77 mg/L. The 21-day NOEC based on reproduction rate was 10 mg/L.
Based on the limited detail of information available, the reliability of this study cannot be assessed and it is classified as supplementary.
Results synopsis
EC50: 77 mg/L
NOEC: 10 mg/L
Endpoint(s) effected: Reproduction rate
Reference
Description of key information
NOEC (Daphnia magna, 21 d) = 10 mg/L (reproduction rate)
EC50 (Daphnia magna, 21 d) = 77 mg/L (reproduction rate)
Key value for chemical safety assessment
Additional information
A study investigating the long-term toxicity of maleic anhydride to Daphnia magna is published. The study was a performed as a prolonged toxicity test according to a proposal of the German Federal Environmental Agency (1984). The reproduction of Daphnia magna was determined within 21 days of exposure to the substance. A NOEC of 10 mg/L and an EC50 of 77 mg/L were determined (Hüls AG, 1988).
Based on the limited detail on information available for this study, the study is considered not reliable and is hence not used in the chemical safety assessment of maleic anhydride.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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