Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-175-7 | CAS number: 513-88-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1994
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Test type:
- other: only result given
- Limit test:
- no
Test material
- Reference substance name:
- 1,1-dichloroacetone
- EC Number:
- 208-175-7
- EC Name:
- 1,1-dichloroacetone
- Cas Number:
- 513-88-2
- Molecular formula:
- C3H4Cl2O
- IUPAC Name:
- 1,1-dichloropropan-2-one
- Reference substance name:
- 1,1-Dichloro-2-Propanone
- IUPAC Name:
- 1,1-Dichloro-2-Propanone
- Test material form:
- not specified
- Details on test material:
- 1,1-DCP (Aldrich, Milwaukee, WI)
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- CD-1 mice were used in these experiments and were
obtained from Charles River (Portage, MI), held for a
one-week quarantine period, and randomly housed, five
per plastic cage, on hardwood chip bedding (Absorb-
Dri, St. Regis Paper, Garfield, NJ). Purina Lab Chow
and distilled water that had been carbon filtered and
irradiated with ultraviolet light were available ad libitum.
The room in which the animals were housed was
maintained at 20-22°C with 40-60% relative humidity
and 12-hr interval light-dark cycles.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 250 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- LD50 (mice) = 250 mg/kg
- Executive summary:
During determinations of the appropriate doses of
1,1-DCP and 1,3-DCP to administer when measuring
the effects of these compounds on serum enzyme activities,
it became clear that each was, by definition, very
to extremely toxic (the LD50 of 1,1-DCP was 250 mg/
kg and the LD50 of 1,3-DCP was 25 mg/kg; unpublished
data). This finding is of interest because the LD50 for
mice exposed to 2-propanone has ranged from 4000 to
8000 mg/kg (23) (slightly to moderately toxic). Therefore,
chlorination of 2-propanone dramatically increases
its toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
