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EC number: 606-172-9 | CAS number: 1893-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin and eye irritation for the target Pipamperone was estimated by using ACD/Percepta
QSAR model and Toxtree decision rule system
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
ACD/Percepta prediction |
Toxtree prediction |
WoE prediction |
SKIN IRRITANT (Not reliable) |
NOT SKIN IRRITANT (na*) |
NOT SKIN IRRITANT (na*) |
ACD/Percepta predicted Pipamperone as skin irritant, however the prediction was assessed as not reliable since no training compounds with similarity greater than 0.5 with respect to Pipamperone were found.
Toxtree identified three exclusion rules and one inclusion rule for the target Pipamperone. The exclusion rules are the following: i) compounds with melting point greater than 200°C (Pipamperone EPISuite/MPBPVP estimated melting point = 219.65°C); ii) compounds containing C, H, O, N and Halogen (Hal) atoms with molecular weight greater than 300 g/mol (Pipamperone MW = 375.48 g/mol); iii) compounds containing C, H, O, N and Halogen (Hal) atoms with aqueous solubility lower than 0.1 g/L (Pipamperone EPISuite/WSKOWWIN aqueous solubility = 0.08165 g/L). In addition, Toxtree identified the ketone structural alert. Since in the case of conflicting results (i.e. if an exclusion rule and an inclusion rule give contradicting predictions), the exclusion rule takes precedence, it was concluded that Toxtree predicted Pipamperone as not skin irritant. An assessment of the reliability of the prediction is not provided by Toxtree.
Eye irritation
Eye irritation predictions:
ACD/Percepta prediction |
Toxtree prediction |
WoE prediction |
NOT EYE IRRITANT (Not reliable) |
NOT EYE IRRITANT (na*) |
NOT EYE IRRITANT (na*) |
ACD/Percepta predicted Pipamperone as not eye irritant, however the prediction was assessed as not reliable since no training compounds with similarity greater than 0.5 with respect to Pipamperone were found.
Toxtree did not identify any inclusion rule, while it identified three exclusion rules: i) compounds with melting point greater than 200°C (Pipamperone EPISuite/MPBPVP estimated melting point = 219.65°C); ii) compounds containing C, H, O, N and Halogen (Hal) atoms with molecular weight greater than 300 g/mol (Pipamperone MW = 375.48 g/mol); iii) compounds containing C, H, O, N and Halogen (Hal) atoms with aqueous solubility lower than 0.1 g/L (Pipamperone EPISuite/WSKOWWIN aqueous solubility = 0.08165 g/L). Thus, it was concluded that Toxtree predicted Pipamperone as not eye irritant. An assessment of the reliability of the prediction is not provided by Toxtree
Justification for selection of skin irritation / corrosion
endpoint:
In silico prediction
Justification for selection of eye irritation endpoint:
In silico prediction
Justification for classification or non-classification
The two predictors were employed in order to apply a weight of evidence (WoE) approach to enhance the reliability of the prediction. Since ACD/Percepta prediction resulted to be not reliable, based on Toxtree prediction, it was concluded Pipamperonewas predicted as not skin and eye irritant. A detailed assessment of the reliability of the weight of evidence prediction was not possible.
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