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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 254-529-9 | CAS number: 39577-43-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Henry F. Smyth Jr., Charles P. Carpenter, Carrol S. Well, Urbano C. Pozzani & Jean A. Striegel
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal, 1962, 23:2, 95-107
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Primary dermal irritation study was carried out on rabbits to assess the irritation potential of 2-piperazin-1-ylethanol
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-piperazin-1-ylethanol
- EC Number:
- 203-142-3
- EC Name:
- 2-piperazin-1-ylethanol
- Cas Number:
- 103-76-4
- Molecular formula:
- C6H14N2O
- IUPAC Name:
- 2-piperazin-1-ylethanol
- Test material form:
- solid
- Details on test material:
- InChI: 1S/C6H14N2O/c9-6-5-8-3-1-7-2-4-8/h7,9H,1-6H2
Name of the test chemical: N-(2-Hydroxyethyl)piperazine/
Moolecular formula:C6H14N2O
Molecular weight:130.19 g/mol
Physical State: Solid
Constituent 1
- Specific details on test material used for the study:
- InChI: 1S/C6H14N2O/c9-6-5-8-3-1-7-2-4-8/h7,9H,1-6H2
Name of the test chemical: N-(2-Hydroxyethyl)piperazine/
Molecular formula:C6H14N2O
Molecular weight:130.19 g/mol
Physical State: Solid
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- open
- Preparation of test site:
- other: closely clipped, tact rabbit skij
- Vehicle:
- other: solutions in water, acetone, propylene glycol
- Controls:
- not specified
- Amount / concentration applied:
- 0.01 ml of undiluted sample or of solutions in water, acetone, propylene glycol
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 hours
- Number of animals:
- 5
- Details on study design:
- TEST SITE
Area of exposure: closely clipped, intact abdominal skin
% coverage: No data
Type of wrap if used: no wrap used
REMOVAL OF TEST SUBSTANCE
Washing (if done): no data
Time after start of exposure: no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 10
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No irritation was observed
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- Acute dermal irritation study was carried out to assess the irritation potential of N-(2-Hydroxyethyl)piperazine.
Primary Irritation score after 24 hours for N-(2-Hydroxyethyl)piperazine was Grade 1.
Based on this grade, N-(2-Hydroxyethyl)piperazine can be considered not irritating to rabbit skin. - Executive summary:
Acute dermal irritation study was carried out to assess the irritation potential of N-(2-Hydroxyethyl)piperazine.
Primary skin irritation on rabbits was recorded in a 10-grade ordinal series and was based upon the severest reaction that develops on the clipped abdominal skin of each of five albino rabbits within 24 hours of the uncovered application of 0.01 ml of undiluted sample or of solutions in water, propylene glycol, or acetone.
Grade 1 indicates no irritation and Grade 2 the least visible capillary injection from the undiluted chemical. Grade 6 indicates necrosis when undiluted and Grade 10 indicates necrosis from a 0.01% solution
Primary Irritation score after 24 hours for N-(2-Hydroxyethyl)piperazine was Grade 1.
Based on this grade,N-(2-Hydroxyethyl)piperazine can be considered not irritating to rabbit skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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