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EC number: 204-429-6 | CAS number: 120-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The Toxnet website includes a number of exposure related observations regarding 2,4-dichlorophenol. The attached toxnet file gives additional details.
Additional information
The Toxnet website (the downloaded file is attached)
includes a number of examples of human experiences with 2,4
-dichlorophenol.
Signs and symptoms following ingestion include burning pain in the mouth
and throat; white necrotic lesions in mouth, oesophagus and stomach;
abdominal pain, vomiting and bloody diarrhoea; pallor, sweating,
weakness, headache, dizziness, tinnitus; shock; weak irregular pulse,
hypotension, shallow respiration, cyanosis, pallor, and a profound fall
in body temperature; possibly fleeting excitement and confusion,
followed by unconsciousness; stertorous breathing, mucous rales,
rhonchi, frothing at nose and mouth and other signs of pulmonary oedema
are sometimes seen; characteristic odour of phenol on the breath;
scanty, dark-colored urine and moderately severe renal insufficiency may
appear; methemoglobinemia, Heinz body haemolytic anaemia and
hyperbilirubinemia have been reported; death from respiratory,
circulatory or cardiac failure.
If spilled on skin, pain is followed promptly by numbness; the skin becomes blanched and a dry opaque eschar forms over the burn.
A number of case studies have also been reported :-
eg, in 1998, a 29-year-old man employed at a chemical
company producing 2,4-D was sprayed with 2,4-DCP from a leak in tubing
while he was using steam to clear a blocked pump. The worker bypassed
the nearest safety shower and used a locker room shower, where he became
unconscious. Resuscitation attempts were unsuccessful and the worker was
pronounced dead at a hospital 1 hour after exposure. Skin surfaces
exposed to 2,4-DCP included his forearms, right knee, right thigh, and
face. Except for chemical burns on his face and extremities and
pulmonary oedema, the autopsy findings were unremarkable. 2,4-DCP was
found in his blood (7.2 mg/L free 2,4-DCP, 13.1 mg/L total 2,4-DCP) and
urine (4.8 mg/L free 2,4-DCP, 6.2 mg/L total 2,4-DCP). Death was
attributed to acute dichlorophenol intoxication.
eg In 1991, a 33-year-old man working at a factory was splattered over
portions of his right thigh and arm with pure liquid 2,4-DCP while
disposing of industrial waste. He walked away from the scene and washed
himself with water without undressing. He experienced a seizure,
collapsed within 20 minutes of exposure and died after unsuccessful
attempts at resuscitation. 2,4-DCP was found in his blood (24.3 mg/L),
urine (5.3 mg/L), bile (18.7 mg/L), and stomach (1.2 mg/L).
Additional case study examples and other background data
on 2,4-dichlorophenol can be found in the attached document.
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