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EC number: 947-640-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24/07/2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Study performed according to international guidelines but not under GLP.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-vinyl-1,3-dioxolane
- EC Number:
- 223-626-8
- EC Name:
- 2-vinyl-1,3-dioxolane
- Cas Number:
- 3984-22-3
- Molecular formula:
- C5H8O2
- IUPAC Name:
- 2-vinyl-1,3-dioxolane
- Reference substance name:
- Toluene
- EC Number:
- 203-625-9
- EC Name:
- Toluene
- Cas Number:
- 108-88-3
- Molecular formula:
- C7H8
- IUPAC Name:
- toluene
- Test material form:
- liquid
- Details on test material:
- Batch No.: LF-238-042-F3
Name of test material (as cited in study report): 2-VINYL-1,3-DIOXOLANE
Physical state: colourless liquid
Storage conditions: ambient temperature, protected from light
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Source: Elevage IFFA CREDO (69210 L'Arbresle, France)
Age: between 5 and 7 weeks
Number and sex: 5 males and 5 female
Acclimation period: during 5 days before the beginning of the test.
Housing: 5 animals per cage
Diet: Pelleted complete rat diet "A04-10" (UAR, 91360 Epinay sur Orge, France)
Water: water acidified at pH = 2.5
ENVIRONMENTAL CONDITIONS
Temperature: 22 ± 2 °C
Humidity: 50 ± 20 %
Air changes: 10/h
Photoperiod: 12 h dark / 12 h light
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME ADMINISTERED: 2 mL/kg bw (corresponding to 2000 mg/kg bw)
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 females and 5 males at 2000 mg/kg
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing
Clinical signs and mortality: Animals were observed for any behavioural or toxic effects at 30 minutes, 1, 2, 3, 4, 5 and 6h after administration of the item and thereafter once a day until Day 14.
Bodyweight was recorded on Day-1, at day 1 after administration, and at day 4, 8 and 15 (i.e 3, 7, 14 days after administration of the test item)
- Necropsy of survivors performed: Yes; On Day 15, animals were anaesthetised with sodium pentobarbital 6% at a concentration of 1.16 mL/kg before a macroscopic examination. - Statistics:
- None
Results and discussion
- Preliminary study:
- Not Applicable
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- < 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: all animals were dead between 30 and 60 minutes after gavage administration
- Mortality:
- The death of all animals was observed between 30 and 60 minutes after gavage administration.
The autopsy carried out on animals showed damages on stomach and duodenum on all animals. - Clinical signs:
- Not applicable
- Body weight:
- Not applicable
- Gross pathology:
- Not applicable
- Other findings:
- None
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The oral LD50 for REACTION MASS OF TOLUENE AND 2-VINYL-1,3-DIOXOLANE is lower than 2000 mg/kg bw. An additionnal test at 200 mg/kg is necessary to determine the LD50 of the test substance and its classification.
- Executive summary:
In an acute oral toxicity study (limit test) performed according to OECD Guideline 401, 10 Sprague Dawley female and male rats (5 males and 5 females) were given a single oral (gavage) dose of REACTION MASS OF TOLUENE AND 2 -VINYL-1,3 -DIOXOLANE at 2000 mg/kg bw. Animals were then observed for mortality, clinical signs and bodyweights for 14 days and were all sacrificed for macroscopic examination.
The death of all animals was observed between 30 and 60 minutes after gavage administration. The autopsy carried out on animals showed damages on stomach and duodenum on all animals.
Therefore, the oral LD50 for REACTION MASS OF TOLUENE AND 2-VINYL-1,3-DIOXOLANE is lower than 2000 mg/kg bw. An additionnal test at 200 mg/kg is necessary to determine the LD50 of the test substance and its classification.
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