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EC number: 202-485-6 | CAS number: 96-17-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The oral LD50 of 2-methylbutyraldehyde was determined to be 6880 mg/kg bw in male rats (Carpenter, 1974).
The inhalation LC50 of 2-methylbutyraldehyde was determined to be 50.5 mg/L in rats (Carpenter, 1974).
The dermal LD50 of 2-methylbutyraldehyde was determined to be 5400 mg/kg in male rabbits (Carpenter, 1974).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 6 880 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 50 500 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 400 mg/kg bw
Additional information
For the assessment of the acute toxicity of 2-methylbutyraldehyde (2 -methylbutanal), only one valid study is available which covers all three exposure routes (Carpenter 1974). The data reported by Carpenter are based on the study conducted by Weil for Union Carbide Corporation (Weil, 1970).
Acute toxicity: oral
The acute oral toxicity of 2-methylbutyraldehyde was determined in groups of 5 male Carworth-Wistar rats receiving the test material by oral gavage at doses of 3.2, 6.4, 12.9, and 25.7 g/kg bw. The observation period was 14 days. The LD50 and a range of ± 1.96 SD was calculated according to the method of Thomson (1947). Overall, the study was conducted in accordance with the recently retracted OECD test guideline 401.
The acute oral LD50 was determined to be 6880 mg/kg bw in rats (Carpenter, 1974).
Acute toxicity: inhalation
For this acute inhalation toxicity study, a standard graduate dose test and an inhalation hazard test were performed. The observation period for both tests was 14 days.
Groups of six albino rats were exposed for 4 hours to 2-methylbutyraldehyde vapor in the breathing atmosphere of test animals at doses of 17.9, 35.8, and 71.6 mg/L.
In the inhalation hazard test, test animals were exposed for various time periods starting from several minutes up to 8 hours if appropriate (spacing factor of 2) to an atmosphere saturated or close to saturation with vapors of 2-methylbutyraldehyde. Actual atmosphere concentrations were not measured but can be estimated to be saturated or close to saturation by the method the atmosphere was generated.
In the inhalation hazard test (saturated vapor), the exposure time was restricted to 10 min in order to produce no mortality (LT50 = 14.1 min).
The LC50 for 2-methylbutyraldehyde was determined to be 50.5 mg/L in rats (Carpenter, 1974).
Standards of the OECD test guideline 403 (Acute Inhalation Toxicity) are only met with restrictions by this investigation (LC 50 value not statistically derived, only 6 rats used, no concentrations measured, deficiencies in reporting). The deviations from the test guideline are considered not to invalidate the result.
Acute toxicity: dermal
The acute dermal toxicity of 2-methylbutyraldehyde was determined in groups of 4 male albino New Zealand rabbits receiving doses of 3213, 6426, and 12853 mg/kg bw. The exposure time was 24 hours followed by an observation period of 14 days. From mortality data, the LD50 and a range of ± 1.96 SD was calculated according to the method of Thomson (1947).
The acute dermal LD50 for 2-methylbutyaldehyde was determined to be 5400 mg/kg bw in rabbits (Carpenter, 1974).
Overall, the study was conducted similar to OECD test guideline 402 with some restrictions (only 4 animals per group, occlusive wrapping, limited reporting). The deviations from the test guideline are considered not to invalidate the result.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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