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EC number: 225-533-8 | CAS number: 4904-61-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- DuPont Co. (1999). Haskell Laboratory Report No. DuPont-1559 (unpublished);|cited in DuPont Co. (2001). Robust summary for 1,5,9-cyclododecatriene. Submitted to U.S. EPA on 11 Dec. 2001. Also cited in TSCA fiche OTS0557883-1
- Reference Type:
- publication
- Title:
- Evaluation of the potential developental toxicity of cyclodedecatriene (CDDT).
- Author:
- Munley SM, Kelly DP and Kennedy GL jr.
- Year:
- 2 003
- Bibliographic source:
- Drug Chem. Toxicol. 26 (3), 199-212.
- Reference Type:
- publication
- Title:
- Robust summary for 1,5,9-cyclododecatriene (revised).
- Author:
- DuPont Safety, Health & Environmental Excellence Center, Wilmington (Del., USA)
- Year:
- 2 003
- Bibliographic source:
- U.S. EPA, 46 pp
Materials and methods
- Principles of method if other than guideline:
- Method: details see reference
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- 1,5,9-cyclododecatriene
- IUPAC Name:
- 1,5,9-cyclododecatriene
- Reference substance name:
- Cyclododeca-1,5,9-triene
- EC Number:
- 225-533-8
- EC Name:
- Cyclododeca-1,5,9-triene
- Cas Number:
- 4904-61-4
- Molecular formula:
- C12H18
- IUPAC Name:
- cyclododeca-1,5,9-triene
- Details on test material:
- 1,5,9-cyclododecatriene of DuPont Nylon, purity 99.83%
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD (SD)BR
- Details on test animals or test system and environmental conditions:
- TEST ORGANISMS
- Source: Charles River Breeding Laboratories, Raleigh (North Carolina, USA)
- females; age: 51-70 days when received (at 1, 2, or 3 days of gestation); 5, 4, or 3 days acclimation
- Number of animals: 22 per exposure concentration
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure (if applicable):
- whole body
- Vehicle:
- air
- Details on exposure:
- ADMINISTRATION / EXPOSURE
- Type of exposure: whole-body
- Concentrations: 10 / 25 / 75 ppm (target)
- Type or preparation of particles: Controlled flows of high-pressure air and liquid test substance through heated mixing flask (approx. 240 °C), dilution with additional air, total airflow 60 l/min (target; measured: 59 - 62 l/min).
- Exposure chamber temperature: target 22 +/- 2 °C; measured 22 - 27 °C - Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- - Concentration monitoring: known volume samples from breathing zone at 60 minute intervals; passage through glass fiber filter followed by glass impinger with hexane as collection medium; weighing of filter before and after sampling; GC / FID analysis of hexane solution, quantification with standard curve.
- Particle size (high test concentration, 3 measurements): MMAD 5.4 / 1.5 / 0.76 µm, mean 2.6 µm, with 13-56% of the particles < 1 µm; 35-89% < 3 µm; 66-99% < 10 µm.
-further details: see references - Details on mating procedure:
- -mated by supplier
- Duration of treatment / exposure:
- days 6-20 of gestation
- Frequency of treatment:
- 6 hours/day
- Duration of test:
- Duration of test: 16 days
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
10; 25; 67 ppm = 67.5; 169; 452 mg/m3
Basis:
nominal conc.
- Remarks:
- Doses / Concentrations:
10 +/- 0.27 ppm; 25 +/- 0.33 ppm; 67 +/- 1.9 ppm
Basis:
analytical conc.
- No. of animals per sex per dose:
- 22 per exposure concentration
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Sex: female
Examinations
- Maternal examinations:
- PARAMETERS ASSESSED DURING STUDY:
- Body weight gain: days 0, 6, 8, 10, 12, 14, 16, 18, 20, 21
- Food consumption: days 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 21
- Clinical observations: once daily (before onset of exposure; including day 21), on exposure days also 1 h after exposure
ORGANS EXAMINED AT NECROPSY (MACROSCOPIC AND MICROSCOPIC): Study terminated on day 21
- Macroscopic: Organs of the thoracic and abdominal cavities - Ovaries and uterine content:
- - Examination of uterine content: type (live and dead fetuses, and resorptions) and relative positions
- Fetal examinations:
- - Examination of fetuses: body weight, sex, and external alterations; visceral alterations and stages of renal papillary development (live fetuses 1, 3, 5 etc. for each litter), skeletal alterations (all live fetuses)
- Statistics:
- STATISTICAL METHODS:
- Maternal weight, weight change, food consumption: parametric linear contrast of means
- Incidence data (pregnancy, clinical observations): Cochran-Armitage test
- Reproductive outcome data and fetal alteration data: Jonckheere's test; at > 75 % ties: permutation methodology
- Mean fetal weight, sex ratio: Analysis of variance (ANOVA), applying a parametric linear contrast of least square means
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Details on maternal toxic effects:
MATERNAL TOXIC EFFECTS BY DOSE LEVEL:
- Mortality and day of death: no deaths
- Description, severity, time of onset and duration of clinical signs: 10 ppm: no effect; 25 ppm: increase in facial staining; 67 ppm: diminished response to alerting stimulus; stained and/or wet fur, staining was considered to be the result of increased lacrimation and salivation and decreased grooming.
- Body weight: statistically significant decrease at mid and high dose beginning on day 8; data for day 21: 25 ppm: -5.3% absolute, -5.6% corrected for uterine content 67 ppm: -14.8% absolute, -15.0% corrected for uterine content increase day 6-21 (also statistically significant): 25 ppm: -14.5% absolute, -30.8% corrected for uterine content 67 ppm: -36.0% absolute, -69.6% corrected for uterine content At 10 ppm, statistically significant but minimal (3-4 %) and transient differences to control in weight increase were observed during the first week.
- Food/water consumption: The maternal weight data corresponded to food consumption values, which were reduced at 25 (-9%) and 67 (-28%) ppm but unaffected at 10 ppm.
- Number pregnant per dose level = number of litters: 0 ppm: 21; 10 ppm: 20; 25 ppm: 22; 67 ppm: 20. ==> no effect
- Number aborting: none - Number of resorptions (mean): 0 ppm: 1.0; 10 ppm: 0.7; 25 ppm: 0.4; 67 ppm: 0.7 ==> no effect
- Number of implantations (mean): 0 ppm: 14.1; 10 ppm: 14.1; 25 ppm: 13.3; 67 ppm: 13.8 ==> no effect
- Pre and post implantation loss: none - Number of corpora lutea (mean): 0 ppm: 15.6; 10 ppm: 15.4; 25 ppm: 14.8; 67 ppm: 15.0 ==> no effect
Effect levels (maternal animals)
open allclose all
- Dose descriptor:
- NOEL
- Effect level:
- 10 ppm
- Basis for effect level:
- other: maternal toxicity
- Dose descriptor:
- NOEL
- Effect level:
- 25 ppm
- Basis for effect level:
- other: developmental toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Details on embryotoxic / teratogenic effects:
FETAL DATA:
- Litter size and weights (mean): 0 ppm: 13.1 fetuses (6.9 males + 6.2 females) with 5.68 g mean weight 10 ppm: 13.4 fetuses (7.1 males + 6.4 females) with 5.63 g mean weight 25 ppm: 13.0 fetuses (6.6 males + 6.4 females) with 5.55 g mean weight 67 ppm: 13.1 fetuses (6.5 males + 6.7 females) with 4.93 g mean weight ==> statistically significant effect on weight (-13.2%) at 67 ppm
- Number viable: all live
- Sex ratio: male/total = 0.53 / 0.52 / 0.50 / 0.49 ==> no effect
- Grossly visible abnormalities: no effect observed
- External abnormalities: no effect observed
- Skeletal abnormalities: Compound related, statistically significant increase in incidence of delayed skeletal ossification:
- sternebrae: 0 ppm: -; 10 ppm: 1 fetus; 25 ppm: 2 fetuses (2 litters); 67 ppm: 8 fetuses (5 litters): considered compound-related and consistent with reduced fetal weight.
- vertebrae: 0 ppm: 113 fetuses (21 litters) 10 ppm: 123 (20); 25 ppm: 134 (22); 67 ppm: 136 (20): not considered toxicologically relevant based on high background incidence; well within the control range of four studies from the same time: 128-161 fetuses in 23-25 litters.
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
Result: no selective developmental toxicant
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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