Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-492-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study meets the criteria for Klimisch code 1 because it followed an internationally recognised method (OECD Guideline 203) and was carried out to Good Laboratory Practice.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Remarks:
- None reported
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Total organic carbon (TOC) measurements of each freshly prepared test solution and control and after 24-hours on test just before daily
renewal with fresh test solution. - Vehicle:
- no
- Details on test solutions:
- Individual water accommodated fractions (WAFs) were prepared for each daily renewal of the 10,000 mg/L test level.
A measured weight of test material was added to a measured volume of dilution water (15 L) in a glass vessel and stirred for 16 to 24 hour.
Stirring was accomplished using a Telfon coated magnetic stir bar.
Following the mixing period, the test solution were allowed to stand for 2 hours before the water phase was removed.
The water phase was siphoned from the middle of the vessels and was used for the toxicity test.
Dilution water was natural seawater collected from Cape Cod Canal, Bourne, Massachusetts. Water was filtered through a 0.5 micron polypropylene core filter and then activated carbon. Water was stored under constant aeration for 1-4 days prior to use.
No undissolved test material was reported on the surface of the test vessels during the entire toxicity test. - Test organisms (species):
- Cyprinodon variegatus
- Details on test organisms:
- TEST ORGANISM
- Common name: Sheepshead minnow
- Source: Commercial supplier in New Hampshire
- Age at study initiation: 10 to 15 days old
- Length at study initiation: Average 11 mm, range 10-13 mm, n=30
- Weight at study initiation: Average 0.028 g, range 0.02-0.05 g, n=30
- Feeding during test: The fish were not fed during the test
- Loading biomass: 0.056 g biomass/L
ACCLIMATION
- Acclimation period: Fish were held for a minimum of 6 days prior to testing
- Pretreatment: None - Test type:
- other: Static renewal
- Water media type:
- saltwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- Not reported
- Hardness:
- Not relevant
- Test temperature:
- 22 to 23°C
- pH:
- 7.9 to 8.1
- Dissolved oxygen:
- 5.5 mg/L to above 100% saturation (7.2 mg/L)
- Salinity:
- 32 to 34 ppt
- Nominal and measured concentrations:
- Mean measured TOC levels in the control and 10,000 mg/L WAF test level were 3.0 mg/L (range 1.2 to 4.4) and 6.4 mg/L (range 5.0 to 7.9),
respectively - Details on test conditions:
- TEST SYSTEM
- Test vessel: 5 L vessel
- Renewal rate of test solution (frequency/flow rate): About 90% of the test solution in each vessel renewed daily after 24, 48 and 72 hours.
- No. of organisms per vessel: Ten
- No. of vessels per concentration (replicates): Two
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Natural seawater collected from Cape Cod Canal, Bourne, Massachusetts
EFFECT PARAMETERS MEASURED: Mortality and signs of toxicity
TEST CONCENTRATIONS
- Test concentrations: Control and 10,000 mg/L WAF loading rate - Reference substance (positive control):
- yes
- Remarks:
- Sodium laurl sulfate (SLS).
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LL0
- Effect conc.:
- > 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: WAF loading rate
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LL50
- Effect conc.:
- > 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: WAF loading rate
- Basis for effect:
- mortality (fish)
- Details on results:
- Control mortality did not exceed the test validity criterion (i.e. <10% mortality in controls).
No mortality or signs of toxicity were noted in either the control or the 10,000 mg/L WAF treatment throughout the test. - Results with reference substance (positive control):
- 96 hour LC50 was 1.2 mg/L
- Reported statistics and error estimates:
- Statistical analysis of the data was not warranted on the basis that no mortality occurred in this study.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance was not toxic to the Sheepshead minnow (Cyprinidon variegatus) at a loading of 10000 mg/L nominal WAF
- Executive summary:
In a 96-hour acute toxicity study, Sheepshead minnow (Cyprinidon variegatus) were exposed to benzenesulphonic acid C20-24 alkyl calcium salt at nominal concentrations of 0 and 10,000 mg/L WAF under static renewal conditions. The 96-hour LL50was >10,000 mg/L nominal WAF. No signs of toxicity were noted.
This toxicity study is classified as acceptable and satisfies the guideline requirement for a fish acute toxicity study.
Results Synopsis
Test organism size/age (mean wet weight or length): 10 to 15 days old, average length 11 mm average weight 0.028 g
Test Type: Static renewal
LL50: >10,000 mg/L nominal WAF
LL0: 10,000 mg/L nominal WAF
Endpoint(s) Effected: None
Reference
Description of key information
The toxcity of the substance has been measured experimentally with freshwater fish. Due to the extremely low water solubility all studies have been conducted using Water Accomodated Fractions and completed as limit tests.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 000 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 10 000 mg/L
Additional information
The LC50 in freshwater fish is considered to be >1000 mg/l and >10000 mg/l with marine species. The substance is, therefore, considered not toxic to freshwater or marine fish species. Nevertheless, adequate controls will be in place during production and use to ensure that the substance is not released to the environment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.