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EC number: 297-629-8 | CAS number: 93685-81-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2000/03/08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report equivalent or similar to OECD guideline 405: GLP.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2000/03/08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report equivalent or similar to OECD guideline 405: GLP.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- No corneal damage or iridial inflammation was observed. Only slight signs of irritation were observed in the rabbits.
- Interpretation of results:
- other: Not irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The mean conjunctivae, chemosis, iris, and cornea scores for the Sample V were 0.0, 0.0, 0.0, and 0.0 respectively. Classification as an ocular irritant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
- Executive summary:
This data is being read across from the source study that tested Hydrocarbons, C10-C12, isoalkanes,, <2% aromatics based on analogue read across.
Sample V (0.1 mL, neat) was administered to the right eye of three rabbits to assess for occular irritation. Irritation and toxicity were monitored at 1, 24, 48, and 72 hours post-treatment. Irritation was scored according to the Draize methodology. No corneal damage or iridial inflammation was observed. Only slight signs of irritation were observed in the rabbits. The mean conjunctivae, chemosis, iris, and cornea scores for sample V were 0.0, 0.0, 0.0, and 0.0 respectively. Classification as an ocular irritant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
Irritation parameter | Basis | Time Point | Score |
conjuctivae score | animal #1 | 24 hours | 0 |
conjuctivae score | animal #2 | 24 hours | 0 |
conjuctivae score | animal #3 | 24 hours | 0 |
conjuctivae score | animal #1 | 48 hours | 0 |
conjuctivae score | animal #2 | 48 hours | 0 |
conjuctivae score | animal #3 | 48 hours | 0 |
conjuctivae score | animal #1 | 72 hours | 0 |
conjuctivae score | animal #2 | 72 hours | 0 |
conjuctivae score | animal #3 | 72 hours | 0 |
conjuctivae score | mean | 24 hour mean | 0 |
conjuctivae score | mean | 48 hour mean | 0 |
conjuctivae score | mean | 72 hour mean | 0 |
conjuctivae score | mean | 24-72 hour mean | 0 |
chemosis score | animal #1 | 24 hours | 0 |
chemosis score | animal #2 | 24 hours | 0 |
chemosis score | animal #3 | 24 hours | 0 |
chemosis score | animal #1 | 48 hours | 0 |
chemosis score | animal #2 | 48 hours | 0 |
chemosis score | animal #3 | 48 hours | 0 |
chemosis score | animal #1 | 72 hours | 0 |
chemosis score | animal #2 | 72 hours | 0 |
chemosis score | animal #3 | 72 hours | 0 |
chemosis score | mean | 24 hour mean | 0 |
chemosis score | mean | 48 hour mean | 0 |
chemosis score | mean | 72 hour mean | 0 |
chemosis score | mean | 24-72 hour mean | 0 |
cornea score | mean | 24-72 hour mean | 0 |
iris score | mean | 24-72 hour mean | 0 |
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Hydrocarbons, C10-C12, isoalkanes, <2% aromatics
- EC Number:
- 923-037-2
- IUPAC Name:
- Hydrocarbons, C10-C12, isoalkanes, <2% aromatics
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Harlan UK Ltd
- Age at study initiation: 13 weeks
- Weight at study initiation: 2.7 - 3.2 kg
- Housing: individual
- Diet (e.g. ad libitum): Special Diet Services STANRAB SQC pellet, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 25 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.5 -23
- Humidity (%): 36-45
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: contralateral eye
- Amount / concentration applied:
- 0.1mL
- Duration of treatment / exposure:
- The eyelids were gently held together for one second before releasing.
- Observation period (in vivo):
- 1, 24, 48, and 72 hours post-treatment
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- Test material was applied to the eyes and the eyelids were gently held together for one second before releasing. Irritation and toxicity were monitored at 1, 24, 48, and 72 hours post-treatment. Irritation was scored according to the Draize methodology.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- No corneal damage or iridial inflammation was observed. Only slight signs of irritation were observed in the rabbits.
Any other information on results incl. tables
Irritation parameter | Basis | Time Point | Score |
conjuctivae score | animal #1 | 24 hours | 0 |
conjuctivae score | animal #2 | 24 hours | 0 |
conjuctivae score | animal #3 | 24 hours | 0 |
conjuctivae score | animal #1 | 48 hours | 0 |
conjuctivae score | animal #2 | 48 hours | 0 |
conjuctivae score | animal #3 | 48 hours | 0 |
conjuctivae score | animal #1 | 72 hours | 0 |
conjuctivae score | animal #2 | 72 hours | 0 |
conjuctivae score | animal #3 | 72 hours | 0 |
conjuctivae score | mean | 24 hour mean | 0 |
conjuctivae score | mean | 48 hour mean | 0 |
conjuctivae score | mean | 72 hour mean | 0 |
conjuctivae score | mean | 24-72 hour mean | 0 |
chemosis score | animal #1 | 24 hours | 0 |
chemosis score | animal #2 | 24 hours | 0 |
chemosis score | animal #3 | 24 hours | 0 |
chemosis score | animal #1 | 48 hours | 0 |
chemosis score | animal #2 | 48 hours | 0 |
chemosis score | animal #3 | 48 hours | 0 |
chemosis score | animal #1 | 72 hours | 0 |
chemosis score | animal #2 | 72 hours | 0 |
chemosis score | animal #3 | 72 hours | 0 |
chemosis score | mean | 24 hour mean | 0 |
chemosis score | mean | 48 hour mean | 0 |
chemosis score | mean | 72 hour mean | 0 |
chemosis score | mean | 24-72 hour mean | 0 |
cornea score | mean | 24-72 hour mean | 0 |
iris score | mean | 24-72 hour mean | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The mean conjunctivae, chemosis, iris, and cornea scores for the Sample V were 0.0, 0.0, 0.0, and 0.0 respectively. Classification as an ocular irritant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
- Executive summary:
Sample V (0.1 mL, neat) was administered to the right eye of three rabbits to assess for occular irritation. Irritation and toxicity were monitored at 1, 24, 48, and 72 hours post-treatment. Irritation was scored according to the Draize methodology. No corneal damage or iridial inflammation was observed. Only slight signs of irritation were observed in the rabbits. The mean conjunctivae, chemosis, iris, and cornea scores for sample V were 0.0, 0.0, 0.0, and 0.0 respectively. Classification as an ocular irritant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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