Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-289-9 | CAS number: 137-32-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented, scientifically acceptable publication For justification of read across please refer to section 13.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Penetration of low-molecular-weight alcohols into skin. Effect of concentration of alcohol and type of vehicle
- Author:
- Blank IH
- Year:
- 1 964
- Bibliographic source:
- Journal of Investigative Dermatology, 43(5), 415-420
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- RIFM
- Year:
- 2 009
- Bibliographic source:
- RIFM database
- Reference Type:
- secondary source
- Title:
- 1-Pentanol
- Author:
- Rowe VK and McCollister SB
- Year:
- 1 982
- Bibliographic source:
- Patty's Industrial Hygiene and Toxicology, 3rd rev. ed., Wiley, New York, pp. 4527–4708
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Skin penetration was studied quantitatively using excised human skin.
- GLP compliance:
- no
Test material
- Reference substance name:
- Pentan-1-ol
- EC Number:
- 200-752-1
- EC Name:
- Pentan-1-ol
- Cas Number:
- 71-41-0
- Molecular formula:
- C5H12O
- IUPAC Name:
- pentan-1-ol
Constituent 1
Test animals
- Species:
- human
- Sex:
- not specified
Administration / exposure
- Vehicle:
- other: saline, olive oil
- Duration of exposure:
- no data
- Control animals:
- yes
- Remarks:
- other alcohols
- Details on study design:
- Test:
- human abdominal skin, removed at autopsy within 12 hr of death
Results and discussion
- Absorption in different matrices:
- As the solubility of the alcohols in nonpolar liquids increases from methanol to octanol, the rate of penetration from an aqueous solution also increases. The alcohols penetrate more rapidly from vehicles in which they are less soluble. The rate of penetration of n-amyl alcohol from saline is about 20 times that of ethanol and about one-ninth that of octanol.
Any other information on results incl. tables
The rate of penetration of n-amyl alcohol from a solution of olive oil does not continue to increase as the concentration becomes high; the rate becomes maximal at given point and thereafter decreases as the concentration continues to rise.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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