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EC number: 939-340-8 | CAS number: 28182-81-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
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- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 Apr - 28 Apr 1983
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study conducted according to the OECD TG 405.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- 1981
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Reference substance 001
- Cas Number:
- 28182-81-2
- Molecular formula:
- Unspecified (UVCB substance)
- Reference substance name:
- HDI oligomers, biuret
- EC Number:
- 939-340-8
- Cas Number:
- 28182-81-2
- Molecular formula:
- (C8H12N2O2)n
- IUPAC Name:
- HDI oligomers, biuret
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Designation as given in study report: Albinos Hy/Cr, derived from NZW
- Source: Elevage Charles River France, Saint Aubin-lès-Elbeuf, France
- Weight at study initiation: 2 - 3.5 kg
- Housing: individually in stainless steel cages
- Diet: UAR 112 diet pellets (Société UAR, Epinay-sur-Orge, France), 150 g per animal and day
- Water: tap water, ad libitum
- Acclimation period: at least 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 40 - 70
- Air changes (per hr): 14
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the untreated left eye served for control
- Amount / concentration applied:
- The test article was applied undiluted at an amount of 0.1 mL into the conjunctival sac of the right eye of each animal. The lids were then gently held together for about one second to prevent loss of the test article.
- Duration of treatment / exposure:
- The treated eyes were not rinsed; the first examination was done one hour after instillation of the test article in the conjunctival sac.
- Observation period (in vivo):
- 72 hours
Reading time points: 1, 24, 48 and 72 hours after application - Number of animals or in vitro replicates:
- Three male animals
- Details on study design:
- The irritation was assessed according to the OECD guideline and the findings were scored as recommended by the guideline, according to the numerical Draize scoring system.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: 1, 2 and 3, respectively
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility: not applicable
- Remarks on result:
- other: none of the 3 animals showed corneal opacity due to treatment
- Irritation parameter:
- iris score
- Basis:
- animal: 1, 2 and 3, respectively
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: reversibility: not applicable
- Remarks on result:
- other: none of the 3 animals showed effects in the iris due to treatment
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 0.66
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: conjunctival redness grade 1 was reported for this animal after 1, 24 and 48 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 0.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: conjunctival redness grade 1 was reported for this animal after 1 and 24 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 0.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: conjunctival redness grade 1 was reported for this animal after 1 and 24 h
- Irritation parameter:
- chemosis score
- Basis:
- animal: 1, 2 and 3, respectively
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility: not applicable
- Remarks on result:
- other: none of the 3 animals showed chemosis due to treatment
- Irritant / corrosive response data:
- After 1 and 24 hour following application all 3 animals displayed conjunctival redness grade 1. At reading time point 48 h, reversibility was achieved in 2 cases whereas the third animal still showed conjunctival redness grade 1. At reading time point 72 h, reversibility was also achieved in the third animal. No further effects were seen.
- Other effects:
- Neither toxic symptoms nor mortality were observed.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified
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